Results 221 to 230 of about 2,261,771 (384)

Binge drinking: Health impact, prevalence, correlates and interventions

Psychology and Health, 2017
Emmanuel Kuntsche, S. Kuntsche, Johannes Thrul, G. Gmel   +3 more
semanticscholar   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Exploring the motives for drinking less alcohol and attitudes towards abstinence in individuals with low-to-moderate alcohol use - a mixed-methods study. [PDF]

BMC Public Health
Zeiser M, Baumann S, Freyer-Adam J, Ullrich A, John U, Staudt A.   +5 more
europepmc   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Fecal contamination of drinking water from source to point of use and associated factors among households in Debre-Tabor town, Northwest Ethiopia. [PDF]

Trop Dis Travel Med Vaccines
Gebeyehu FG, Bitew BD, Dessie A, Necho YE, Teym A, Adane B, Gelaw YB.   +6 more
europepmc   +1 more source

An Investigation of Activity Concentration of 238U, 232Th, 137Cs and 40K Radionuclides in Drinking Water Resources in Iraqi Kurdistan Region-Erbil

, 2016

openalex   +1 more source

Binge drinking [PDF]

Injury Prevention, 2005
openaire   +2 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Lifestyle Factors and Current Alcohol Consumption Among Japanese Adolescents During the COVID-19 Pandemic: A Nationwide Cross-Sectional Study. [PDF]

Neuropsychopharmacol Rep
Nishiwaki M, Kanda H, Yoshida K, Hisamatsu T, Kinjo A, Kuwabara Y, Kim H, Imamoto A, Yoshimoto H, Ito T, Kasuga H, Minobe R, Maesato H, Jike M, Otsuka Y, Itani O, Kaneita Y, Higuchi S, Osaki Y.   +18 more
europepmc   +1 more source

What is moderate drinking? Defining "drinks" and drinking levels.

Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2000
Although the benefits and risks associated with moderate drinking have gained increasing attention in recent years from both researchers and the general public, no universal definition of moderate drinking exists. Most currently used definitions are based on a certain number of drinks consumed in a specific time period.
openaire   +1 more source