Results 61 to 70 of about 2,188,260 (386)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The Risky Business of Binge Drinking Among College Students: Using Risk Models for PSAs and Anti-Drinking Campaigns [PDF]
, 2001 To assist creators of public service announcements and anti-drinking campaigns, this study provides an in-depth examination of the risks of binge drinking from the perspective of college students. Using current risk models for guidance, key elements from
Wolburg, Joyce M.
core +2 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Potability of well water in Kirkuk city Iraq
Tikrit Journal of Pure Science, 2023 The Kirkuk residents had resorted underground water as an alternative to the surface water the present study aims to indicate the quality of these water and demonstrates extent of their suitability drinking.
Salah Aldeen Hassan Saeed +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
A cortical-brainstem circuit predicts and governs compulsive alcohol drinking
Science, 2019 A brain circuit to control alcohol intake Most people are exposed to alcohol at some point in their lives, but only a small fraction will develop a compulsive drinking disorder. Siciliano et al.
Cody A. Siciliano +12 more
semanticscholar +1 more source
Effect of State Coalitions to Reduce Underage Drinking: A National Evaluation [PDF]
, 2006 Summarizes an evaluation of how the RWJF-funded Reducing Underage Drinking Through Coalitions Project to reduce youth drinking changed media coverage of alcohol-related issues, state policy, youth drinking behaviors, and alcohol-related driving ...
Alexander Wagenaar, Deanna Lewis
core
Accessibility of ‘essential’ alcohol in the time of COVID-19: casting light on the blind spots of licensing? [PDF]
, 2020 Among the Australian and UK governments’ responses to the COVID-19 pandemic has been the designation of outlets selling alcohol for off-premise consumption as ‘essential’ services, allowing them to remain open while pubs, hotels and restaurants have ...
Claire, Wilkinson, Reynolds, Joanna
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
MMWR. Morbidity and mortality weekly report, 2019 Drinking alcohol during pregnancy can cause fetal alcohol spectrum disorders (FASDs), including birth defects that involve central nervous system impairment, behavioral disorders, and impaired intellectual development, which can lead to difficulties with
C. Denny +3 more
semanticscholar +1 more source