Results 131 to 140 of about 5,147,496 (260)

Investigating the Efficacy of Topological Methods for Optimal Sensor Placement in Water Distribution Systems

Engineering Proceedings
Water-distribution networks (WDNs) are vital infrastructure that are exposed to the risk of contamination. Several factors contribute to this risk, including insufficient pressure, contamination in water storage tanks and more. Sensor systems are crucial
Ludovica Palma, Armando Di Nardo, Fatemeh Hatam, Giovanni Francesco Santonastaso, Michèle Prévost   +4 more
doaj   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Detection of Complex Formations in an Inland Lake from Sentinel-2 Images Using Atmospheric Corrections and a Fully Connected Deep Neural Network

Remote Sensing
The detection of complex formations, initially suspected to be oil spills, is investigated using atmospherically corrected multispectral satellite images and deep learning techniques.
Damianos F. Mantsis, Anastasia Moumtzidou, Ioannis Lioumbas, Ilias Gialampoukidis, Aikaterini Christodoulou, Alexandros Mentes, Stefanos Vrochidis, Ioannis Kompatsiaris   +7 more
doaj   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Vulnerability assessment of hydrological ecosystem services under future climate and land use change dynamics

Ecological Indicators
Hydrological Ecosystem Services (HESs), as an important part of ecosystem services, are those services that depend on hydrological processes. HESs vulnerability assessment at the watershed scale is used to explore highly vulnerable areas for management ...
Negar Tayebzadeh Moghadam, Bahram Malekmohammadi, Mario Schirmer   +2 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Management of initial notification of a drinking water issue of potential danger to human health

This document is designed to provide guidance to staff of the Health Service Executive (HSE) who work with Uisce Éireann (Public Water Supplies) and with the Local Authorities (Private Water Supplies) in relation to the initial notification of a ...
Health Service Executive (HSE) National Drinking Water Group
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Annual intended use plan. SFY 2021.

, 2020
Annual
Drinking Water Fund (Conn.),
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Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Oregon's Drinking Water Protection Program

, 2009
Title from PDF caption (viewed on January 15, 2020).Converted from HTML.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

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