Results 131 to 140 of about 4,250,637 (303)
Model-driven performance evaluation for service engineering [PDF]
, 2007 Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration.
Boskovic, Marko +2 more
core +3 more sources
Acta Pharmaceutica Sinica BAccurate prediction of protein–ligand complexes and binding affinity is critical for hit identification and optimization for structure-based drug design.
Jing Li +7 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
A theoretical foundation of demand driven web services
, 2014 Web services are playing a pivotal role in business, management, governance, and society with the dramatic development of the Internet and the Web. However, many fundamental issues are still ignored to some extent.
Zhaohao Sun +3 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Data-driven Technologies : Challenges for Privacy and Data Protection Law
Data-driven technologies introduce new privacy risks that are currently not (explicitly) addressed by European data protection law. Against this backdrop, the chapter discusses the general conceptual shortcomings of the GDPR, followed by an overview of ...
Ebers, Martin,, Sein, Karin,
core
Self-hybridisation between interband transitions and Mie modes in dielectric nanoparticles
NanophotonicsWe discuss the possibility of self-hybridisation in high-index dielectric nanoparticles, where Mie modes of electric or magnetic type can couple to the interband transitions of the material, leading to spectral anticrossings.
Tserkezis Christos +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source