Results 111 to 120 of about 4,023,817 (302)

Substrate-assisted cathodoluminescence

npj Nanophotonics
Electron-beam-induced luminescence typically relies on direct excitation by high-energy primary electrons. Here, we explore properties of an alternative excitation approach where cathodoluminescence (CL) is driven by substrate-generated electrons rather ...
Sven Ebel, N. Asger Mortensen, Sergii Morozov   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

BLOW: A Systematic Approach to Behavior-Driven Development in a Layered Organization of Work-Centers

Agile teams often struggle to translate business requirements into maintainable, high-quality software due to the persistent ambiguity in the roles and relationships of behavior-driven development (BDD), Acceptance Test-driven Development (ATDD), and ...
Miguel A. Oltra-Rodríguez, Juan A. Holgado-Terriza, Nicolas Afonso-Alonso, Paul Stonehouse   +3 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Broken ergodicity in driven one-dimensional particle systems with short-range interaction [PDF]

, 2006
We present a one-dimensional nonequilibrium model for a driven di usive system which has local interactions and slow nonconservative reaction kinetics.
Schütz, G. M., Rákos, Attila Gábor
core   +1 more source

Functional associations of the gut microbiome with dopamine, serotonin, and BDNF in schizophrenia: a pilot study

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Schizophrenia is a complex neuropsychiatric disorder with various etiologic factors. Aberrant levels of neurotransmitters or growth factors such as dopamine, serotonin, and BDNF have been shown to cause cognitive impairment in schizophrenia ...
Mahin Ghorbani, Gerard Benedict Stephen Joseph, Tew Mei Mei, Siti Salwa Ramly, Muhammad Arif Muhamad Rasat, Lawrence Croft, Sivachandran Parimannan, Heera Rajandas, Su Yin Lee   +8 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Risk and reward: evaluating household energy storage for optimizing demand-side flexibility under dynamic tariffs

Energy Informatics
Electricity markets increasingly rely on residential demand-side flexibility to integrate renewables and stabilize the grid. While dynamic tariffs can unlock short-term flexibility, they expose households to a risk–reward trade-off. This paper quantifies
Justus Ameling, Robin Thomas Derzbach, Gunther Gust, Christoph Michael Flath   +3 more
doaj   +1 more source