Results 101 to 110 of about 4,250,637 (303)
Model-driven testing with UML 2.0
, 2022 179187The UML 2.0 Testing Profile provides support for UML 2.0 based model-driven testing. This paper introduces a methodology of how to use the profile in order to transform an existing UML system design model for tests.
Dai, Zhen Ru
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Buffer Block Planning for Interconnect-Driven Floorplanning
, 2008 This paper studies buffer block planning for interconnect-driven floorplanning in deep submicron designs. We first introduce the concept of feasible region (FR) for buffer insertion, and derive closed-form formula for FR.
Jason Cong Tianming +2 more
core
Community driven development in fragile contexts
, 2022 This review of community driven development discusses the incentive problems that arise when an external agency attempts to involve the local community in the planning and implementation of development projects.
Hatlebakk, Magnus
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Nature CommunicationsPhotothermal hydrogenation of CO2 offers a solar-driven route to multicarbon hydrocarbons, but controlling carbide formation and maintaining reconstructed active sites remain challenging for iron-based catalysts.
Ling Li +11 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
stefdeli/Data-driven-Adaptive-Benders-Decomposition: Data-Driven Adaptive Benders Decomposition
, 2019 Python codes and data from the paper ``Data-driven Adaptive Benders Decomposition for the Stochastic Unit Commitment ...
Stefanos Delikaraoglou
core +1 more source
npj 2D Materials and ApplicationsThe lowest energy states in transition metal dichalcogenide (TMD) monolayers follow valley selection rules, which have attracted vast interest due to the possibility of encoding and processing of quantum information.
Sergii Morozov +4 more
doaj +1 more source