Results 101 to 110 of about 4,023,817 (302)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Poole -- Model-Driven Architecture. ECOOP 2001.
, 2001 This paper surveys the core OMG MDA standards (i.e., UML, MOF, XMI and CWM) and discusses the current attempts at mapping these standards to J2EE, as examples of PIM-to-PSM translations that are currently under development.
John D. Poole +1 more
core
Data-Driven Control-oriented Modelling of Submerged Arc Furnaces [PDF]
, 2023 openThe present thesis focuses on the integration of chemophysical knowledge and data-driven insights to develop control-oriented models for submerged arc furnaces (SAF).
FORNASIER, PIERANGELO
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Buffer Block Planning for Interconnect-Driven Floorplanning
, 2008 This paper studies buffer block planning for interconnect-driven floorplanning in deep submicron designs. We first introduce the concept of feasible region (FR) for buffer insertion, and derive closed-form formula for FR.
Jason Cong Tianming +2 more
core
npj 2D Materials and ApplicationsThe lowest energy states in transition metal dichalcogenide (TMD) monolayers follow valley selection rules, which have attracted vast interest due to the possibility of encoding and processing of quantum information.
Sergii Morozov +4 more
doaj +1 more source
A Comparison of Spherical Neural Networks for Surround-View Fisheye Image Semantic Segmentation
IEEE Open Journal of Vehicular TechnologyThe automotive industry has made significant strides in enhancing road safety and enabling automated driving features through advanced computer vision techniques.
Anam Manzoor +6 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source