Results 91 to 100 of about 664,595 (265)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Spatiotemporal Dynamics of NEP and Its Influencing Factors: Exploring the Impact Mechanisms Under Extreme Climate Conditions

Remote Sensing
Current research on net ecosystem productivity (NEP) still lacks sufficient attention to the impacts of extreme climate events, particularly in understanding the interactive response mechanisms of carbon sinks under extreme climate conditions. This study
Li Wang, Wei Chen, Wanjuan Song, Ni Huang, Yuelin Zhang, Guoxu Li, Xin Zhang, Yu Peng, Zheng Niu   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Spatiotemporal characteristics and driving factors of wildfires on the Qinghai-Tibetan Plateau

Geomatics, Natural Hazards & Risk
Wildfires have become a global crisis, with alpine regions facing particularly severe challenges. The Qinghai-Tibetan Plateau (QTP), the world's highest plateau, has witnessed a notable increase in both the frequency and extent of wildfires over the past
Nansha Sun, Ruishan Chen, Qiong Chen, Zhenju Zhou, Xiaona Guo, Lilin Zheng   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis of the spatial and temporal evolution and driving factors of landscape ecological risk in Xiaojiang River Basin, Yunnan, China

Geocarto International
Assessing the spatiotemporal evolution of landscape ecological risk (LER) in watersheds and its driving factors is crucial for ecosystem maintenance. This study utilized land use/land cover (LULC) data to establish an LER evaluation model.
Xinrui Yu, Ping Duan, Jun Chang, Jia Li, Qi Nie, Qingquan Zhou   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Study on the Spatio-Temporal Characteristics and Driving Factors of PM_2.5 in the Inter-Provincial Border Region of Eastern China (Jiangsu, Anhui, Shandong, Henan) from 2022 to 2024

Atmosphere
The inter-provincial border region in eastern China, encompassing the junction of Jiangsu, Anhui, Shandong, and Henan provinces, serves as a crucial zone that connects the important economic zones of Beijing–Tianjin–Hebei and the Yangtze River Delta.
Xiaoli Xia, Shangpeng Sun, Xinru Wang, Feifei Shen   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Spatiotemporal Evolution and Driving Factors of the Relationship Between Land Use Carbon Emissions and Ecosystem Service Value in Beijing-Tianjin-Hebei

Land
Land use change significantly affects regional carbon emissions and ecosystem service value (ESV). Under China’s Dual Carbon Goals, this study takes Beijing-Tianjin-Hebei, experiencing rapid land use change, as the study area and counties as the study ...
Anjia Li, Xu Yin, Hui Wei
doaj   +1 more source