Results 91 to 100 of about 17,380,154 (353)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

An Examination of the Spatial Distribution Patterns of National-Level Tourism and Leisure Districts in China and Their Underlying Driving Factors

Buildings
In recent years, tourism and leisure districts have become a pivotal aspect of China’s tourism development. Analyzing their spatial distribution characteristics and driving factors is essential for fostering comprehensive district tourism and promoting ...
Shuangqing Sheng, Huanli Pan, Lei Ning, Zhongqian Zhang, Qiuli Xue   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Stability and change in risky driving from the late teens to the late twenties [PDF]

This paper examines patterns of risky driving from the late teens to the late twenties and identifies factors associated with persistence and change in risky driving tendencies.Key findings: Rates of risky driving remained fairly stable between the ...
Ben Edwards, Julie Lahausse, Suzanne Vassallo   +2 more
core  

Who Should Bear the Risk When Self-Driving Vehicles Crash? [PDF]

, 2021
The moral importance of liability to harm has so far been ignored in the lively debate about what self-driving vehicles should be programmed to do when an accident is inevitable.
Kauppinen, Antti
core  

Glacial Waters Under Threat: Risk Assessment and Source Identification of Polychlorinated Biphenyls in Meili Snow Mountains, Southeastern Tibetan Plateau

Toxics
Polychlorinated biphenyls (PCBs) are classified as persistent organic pollutants (POPs) due to their potential threat to both ecosystems and human health.
Huawei Zhang, Yan Yao, Xinyu Wen, Rui Zhang, Rui Liu   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Driving factors for school milk demand in Germany [PDF]

School milk consumption has declined steadily in Germany. A research project was set up to retrieve quantifiable information on the different factors of influence and to develop solutions to improve the school milk consumption..
Christoph, Inken B., Gonzalez-Mellado, Aida A., Peter, Guenter, Petra, Salamon, Weber, Sascha A.   +4 more
core   +1 more source

Monitoring Vegetation Dynamics and Driving Forces in the Baijiu Golden Triangle Using Multi-Decadal Landsat NDVI and Geodetector Modeling

Land
The China Baijiu Golden Triangle (BGT) serves as the core production hub of China’s Baijiu industry, where the ecological environment plays a pivotal role in ensuring the industry’s sustainable development.
Miao Zhang, Yuanjie Deng, Yifeng Hai, Hang Chen, Aiting Ma, Wenjing Wang, Lu Ming, Huae Dang, Minghong Peng, Dingdi Jize, Cuicui Jiao, Mei Zhang   +11 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source