Results 61 to 70 of about 1,894,819 (256)

Other title: Teen safe driving in Connecticut

open access: yes, 2015
Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws.

core   +1 more source

Driving forces behind prison growth: The mass media

open access: yesNordisk Tidsskrift for Kriminalvidenskab, 1996
See abstract in article.
Thomas Mathiesen
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Predicting the splash of a droplet impinging on solid substrates

open access: yesScientific Reports, 2022
The impingement behaviours of droplets towards solid substrates depend on the liquid properties, impingement velocity and solid surface conditions, such as wettability and roughness.
Yukihiro Yonemoto   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Driving forces and pressures affecting South Africa's inland water resources

open access: yes, 2019
Driving forces and pressures affecting South Africa's inland water ...
Rod Shaw (1258020)   +3 more
core   +1 more source

Understanding Driving Forces and Implications Associated with the Land Use and Land Cover Changes in Portugal [PDF]

open access: yes, 2017
Understanding the processes of land use and land cover changes (LUCC) and the associated driving forces is important for achieving sustainable development.
Susana Pereira   +10 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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