Results 51 to 60 of about 3,693,461 (301)

Ageing and Driving Performance in the UK Using Normal Mixture Model Cluster Analysis Technique

Transactions on Transport Sciences, 2023
This research addresses the issue of an individual's ability to drive and especially of those individuals that are questionably demented (dementia is suspected) or are in a state of very mild dementia and are therefore the most difficult to identify.
Muhammad Tariq Khan, Rawid Khan, Arsalaan Khan   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Cooperative Driving Simulation

, 2016
For a few decades, driving simulators have been supporting research and development of advanced driver assistance systems (ADAS). In the near future, connected vehicles are expected to be deployed.
Nåbo, Arne,, Jansson, Jonas,, Larsson, Tony,, Aramrattana, Maytheewat,   +3 more
core   +1 more source

Comparative Analysis of Driving Performance and Visual and Physiological Responses Between Professional and Civilian Drivers in Simulated Environments

Applied Sciences
Current research and development in understanding road users’ driving behaviors play a key role in improving traffic safety. Recently, several driving simulators have been employed as a suitable approach to investigate several drivers’ responses in ...
Viktor Nagy, Ágoston Pál Sándor, Gábor Kovács, Hanan Elias, Giuseppina Pappalardo   +4 more
doaj   +1 more source

New ideas on how drivers perceive speed emerge from the fog

eLife, 2012
Experiments with a driving simulator contradict previous results by showing that car drivers slow down in fog. However, other forms of reduced visibility can cause drivers to speed up.
Jody C Culham
doaj   +1 more source

Blueprint for a Simulation Framework to Increase Driver Training Safety in North America: Case Study

Safety, 2021
Despite numerous recent advances in the classroom and in-vehicle driver training and education over the last quarter-century, traffic accidents remain a leading cause of mortality for young adults—particularly, those between the ages of 16 and 19 ...
Kevin F. Hulme, Rachel Su Ann Lim, Meghan Bauer, Nailah Hatten, Helena Destro, Brenden Switzer, Jodie-Ann Dequesnay, Rebecca Cashmore, Ian Duncan, Anand Abraham, Jacob Deutsch, Nichaela Bald, Gregory A. Fabiano, Kemper E. Lewis   +13 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Human-Centered Optimization of Expressway Interchange Guide-Sign Infrastructure in Complex Road Networks: Evidence from Visual Behavior, Physiological Responses, and Driving Simulation

Infrastructures
Expressway interchange guide signs must support rapid route decisions under limited viewing time, high information load, and potential vehicle occlusion.
Yanshuang Zhi, Shuzhen Lou, Hongfu Wu, Yingying Luo, Yanqun Yang   +4 more
doaj   +1 more source

Prediction of immediately occurring microsleep events from brain electric signals

Current Directions in Biomedical Engineering, 2016
This contribution addresses the question if imminent changes of the cortical state are predictable. The analysis is based on 1484 examples of microsleep (MS) and 1940 counterexamples of sustained attention (SA), both observed during overnight driving in ...
Golz Martin, Sommer David, Krajewski Jarek   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source