Results 91 to 100 of about 2,535,989 (297)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Investigation of tractor engine power and economical working conditions utilization during transport operation [PDF]

open access: yesTransport, 2008
Article analyzes tractor working and its engine conditions from economical point of view. Overview of tractor wheel slippage reliance on the traction force and weight utilization coefficient is given.
A. Juostas, A. Janulevičius
doaj   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Descriptive statistic results of driving speed.

open access: yes, 2020
Descriptive statistic results of driving speed.
Nengchao Lyu (4389745)   +4 more
core   +1 more source

New design method for horizontal alignment of complex mountain highways based on “trajectory–speed” collaborative decision

open access: yesAdvances in Mechanical Engineering, 2017
The safety evaluation of geometry features design based on actual driving behavior has always been a basic concept of highway design. However, current design methods, including both the design speed method and operating speed method, are still far away ...
Jin Xu, Wei Lin, Yiming Shao
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Modeling the Speed Choice Behaviors of Drivers on Mountainous Roads with Complicated Shapes

open access: yesAdvances in Mechanical Engineering, 2015
Roadway geometric features and pavement conditions can significantly affect driver behavior, particularly with regard to vehicle speed. This paper presents the development of an algorithm for speed selection for use in automated passenger car travel ...
Yiming Shao   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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