Results 71 to 80 of about 2,535,989 (297)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Comparing a driving simulator to the real road regarding distracted driving speed

European Journal of Transport and Infrastructure Research, 2015
Relative and absolute validity of a driving simulator were assessed regarding effects on mean speed and speed variation during distracting secondary tasks, and normal driving.
Allert Knapper, Michiel Christoph, Marjan Hagenzieker, Karel Brookhuis   +3 more
doaj   +1 more source

Can Users Specify Driving Speed? Bench2Drive-Speed: Benchmark and Baselines for Desired-Speed Conditioned Autonomous Driving

CoRR
End-to-end autonomous driving (E2E-AD) has achieved remarkable progress. However, one practical and useful function has been long overlooked: users may wish to customize the desired speed of the policy or specify whether to allow the autonomous vehicle to overtake. To bridge this gap, we present Bench2Drive-Speed, a benchmark with metrics, dataset, and
Yuqian Shao, Xiaosong Jia, Patrick Langechuan Liu, Junchi Yan   +3 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effect of Driving Simulation Parameters Related to Ego-Motion on Speed Perception [PDF]

, 2011
The overall effectiveness of driving simulation as a research tool is linked to how accurately modern technology can model reality. The objective of this project was to conduct a driving simulator experiment to examine the perceptual and behavioral ...
Shaun Durkee, Ward, Nicholas, Durkee, Shaun, Nicholas Ward   +3 more
core   +1 more source

Comparing Powered Wheelchair Driving Characteristics of Real Driving and Two Types of Simulated Driving

IEEE Transactions on Neural Systems and Rehabilitation Engineering
We aimed to gather evidence on the feasibility of using simulator-based driving assessments for prescribing powered mobility devices (PMDs). Therefore, we compared the driving characteristics of real driving and two types of simulated driving.
Myeonghwan Bang, Min A Kim, Myung Joon Lim, Hyoung Seop Kim   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Exploring the Relationship between Speed Choice Behaviour, Hazard Perception and Individual Differences [PDF]

, 2012
Young, and particularly male drivers aged between 15 and 25 years of age are over represented in the crash statistics worldwide. In New Zealand, young drivers (15-24 years) represent only 15% of the driver licensed population but typically contribute to ...
Janse van Vuuren, Stefann
core  

Bus driving behaviour and fuel consumption

, 2012
The behaviour of driver is influenced by many factors, which include the personal characteristics (attitude, experience etc.) environmental (road geometry, traffic control etc.) and vehicle characteristics (performance, load etc.).
Rohani, Munzilah
core   +1 more source