Results 231 to 240 of about 37,452 (297)

Clinical Insights From a Case of Sifrim‐Hitz‐Weiss Syndrome With a CHD4 Variant: Expanding the Phenotypic Spectrum and Its Response to Growth Hormone Therapy

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1403-1410, June 2026.
ABSTRACT To enhance clinicians' understanding of Sifrim‐Hitz‐Weiss syndrome (SIHIWES), this study investigated the clinical phenotypes, genetic characteristics, and response to growth hormone therapy in a patient. A case of a patient with global developmental delay and distinctive facial features is presented.
Jianmei Zhang   +6 more
wiley   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

open access: yesGlia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro   +4 more
wiley   +1 more source

Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood.
Joe W. Chiles III   +23 more
wiley   +1 more source

‘There's No Improvement. I'm Still Bedridden’: Recovery After Hospital Admission for Low Back Pain and Alignment With Patient Expectations

open access: yesMusculoskeletal Care, Volume 24, Issue 2, June 2026.
ABSTRACT Background Patients with non‐serious low back pain (LBP) may present to hospital emergency departments expecting high‐value care when community healthcare options are perceived as inaccessible or ineffective. Objectives This study explored the experiences and expectations of patients following a LBP‐related admission to provide insight into ...
Joseph F. Orlando   +4 more
wiley   +1 more source

A novel hierarchical control strategy for enhancing stability of a DC microgrid feeding a constant power load. [PDF]

open access: yesSci Rep
Louassaa K   +6 more
europepmc   +1 more source

Harnessing the Power of Data to Improve Prostate Cancer Pathways: The South West Prostate Cancer Dashboard

open access: yesTrends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Prostate cancer is now the most frequently diagnosed cancer in UK men. Faster diagnostic pathways form a key component of the NHS Cancer Programme's strategic approach to improving patient outcomes. The Prostate cancer diagnostic pathway involves a number of stages which create potential areas of delay.
Mini Sardar   +7 more
wiley   +1 more source

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