Results 131 to 140 of about 2,435,567 (309)
Water impact analysis of space shuttle solid rocket motor by the finite element method [PDF]
Preliminary analysis showed that the doubly curved triangular shell elements were too stiff for these shell structures. The doubly curved quadrilateral shell elements were found to give much improved results.
Buyukozturk, O. +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Immediate and long-term effects of zero-drop running shoes on lower extremity biomechanics
Frontiers in Bioengineering and BiotechnologyObjectiveThe purpose of the study was to investigate the immediate and long-term effects of zero-drop running shoes on lower extremity joint biomechanics.MethodsSeven male runners participated in this study (height: 1.74 ± 0.03 m, weight: 62.5 ± 3.1 kg ...
Zimeng Liu +7 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Droplet combustion at reduced gravity [PDF]
The current work involves theoretical analyses of the effects identified, experiments in the NASA Lewis drop towers performed in the middeck areas of the Space Shuttle.
Dryer, F. L., Williams, F. A.
core +1 more source
Restore-L Satellite Servicing Internship Final Report [PDF]
, 2019 This paper reviews the Restore-L mission purpose and the necessary research and simulations to meet mission specification for the Propellant Transfer Subsystem (PTS).
Campos, Giovanni
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Calculation Method and Experimental Test of Coiled Tubing Pressure Drop
Shiyou jixie, 2017 Taking the coiled tubing as the study object,the pressure drop of straight tube,bend tube with different radius and varied diameter tube have been calculated and analyzed by using analytic method and finite element method respectively.The maximum ...
Ding Yuqi +5 more
doaj
Vertical Drop Testing and Simulation of Anthropomorphic Test Devices [PDF]
, 2011 A series of 14 vertical impact tests were conducted using Hybrid III 50th Percentile and Hybrid II 50th Percentile Anthropomorphic Test Devices (ATDs) at NASA Langley Research Center.
Littell, Justin D., Polanco, Michael A.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source