Validation of the OptiSafe™ eye irritation test. [PDF]
Cutan Ocul Toxicol, 2020 OptiSafe is an in chemico test method that identifies potential eye irritants based on macromolecular damage following test chemical exposure. The OptiSafe protocol includes a prescreen assessment that identifies test chemicals that are outside the applicability domain of the test method and thus determines the optimal procedure.
Choksi N +13 more
europepmc +4 more sources
Laser Light-Based Opacitometer ‘Peira LLBO 180’: A new and validated opacitometer for use in the Bovine Corneal Opacity and Permeability (BCOP) eye irritation test method [PDF]
MethodsX, 2020 The “Peira LLBO 180” is a Laser Light-Based Opacitometer that can be used as an alternative for the standard OP-KIT device in the Bovine Corneal Opacity and Permeability (BCOP) test Organisation for Economic Co-operation and Development (OECD) Test ...
An R. Van Rompay +2 more
doaj +2 more sources
Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay. [PDF]
Part Fibre Toxicol, 2016 Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging potential of nanomaterials are scarce. Traditionally, eye irritation testing was performed using rabbits. The OECD Test Guideline 437 Bovine Corneal Opacity and Permeability (BCOP) test method allows
Kolle SN +5 more
europepmc +4 more sources
Eye Irritation Test of Soyeom Pharmacopuncture Solution for Eye Drop
Journal of Pharmacopuncture, 2008 Objectives : This study was done to investigate the safety of Soyeom pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
doaj +2 more sources
Development of an Eye Irritation Test Method Using an In-House Fabrication of a Reconstructed Human Cornea-like Epithelium Model for Eye Hazard Identification [PDF]
BioengineeringIn a previous study, a novel human corneal-like epithelium model utilizing an immortalized human corneal epithelial cell line (iHCE-NY1) was developed as an alternative to animal models to identify chemicals not classified under the United Nations ...
Naoki Yamamoto +4 more
doaj +2 more sources
Development and Validation of an In Vitro Ocular Irritation Test for Ophthalmic Medical Devices with a Novel Reconstructed Human Corneal Epithelium Model [PDF]
BioengineeringFor testing ocular irritation, 3D corneal models mimicking the corneal epithelium are considered reliable eye irritation tests and are detailed in regulatory guideline OECD Test Guideline (TG) 492. The aim of the present study was to develop and validate
Payal Rawat +7 more
doaj +2 more sources
Shanghai yufang yixue, 2022 ObjectiveTo establish bovine corneal opacity and permeability （BCOP） test， and determine its predictive ability for the eye irritation evaluation of cosmetics.MethodsA total of ten reference chemicals were selected to establish the BCOP test.
HUO Qian +8 more
doaj +1 more source
Influence of Corneal Staining in Rabbits on the Evaluation of Eye Irritation Test Results
Shiyan dongwu yu bijiao yixue, 2023 Objective To observe the influence of the staining phenomenon after fluorescein sodium staining on eye irritation in normal rabbits. Methods In the experimental rabbit eye irritation test conducted with sodium chloride eye drops, Siwei Zhenceng ...
XU Honghua +6 more
doaj +1 more source
Antimicrobial Stewardship & Healthcare Epidemiology, 2023 Objective: To characterize personal exposures and measures of eye and respiratory tract irritation in controlled environmental chamber studies of 44 healthy adult volunteers simulating upper-bound use of peracetic acid (PAA)–based surface disinfectant ...
Pamela H. Dalton +5 more
doaj +1 more source
Analysis of ocular toxicity of fluconazole and voriconazole eyedrops using HET-CAM [PDF]
Farmacia Hospitalaria, 2014 : Purpose: The objective of the study is to provide toxicological information through the HET-CAM test of Fluconazole and Voriconazole eye drops prepared commonly in Pharmacy Servi - ces for the treatment of fungal keratitis.
A. Fernández-Ferreiro +5 more
doaj +1 more source