Results 11 to 20 of about 7,196,791 (287)

Eye Irritation Test of Bovis Calculus Pharmacopuncture Solutions for Eye Drop

Journal of Pharmacopuncture, 2008
Objective : This study was done to investigate the safety of Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
doaj   +2 more sources

Eye Irritation Test of Fel Ursi Pharmacopuncture Solutions for Eye Drop

Journal of Pharmacopuncture, 2008
Objective : This study was done to investigate the safety of Fel Ursi pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
doaj   +2 more sources

Alternative methods for the replacement of eye irritation testing

ALTEX, 2016
In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye. As the original in vivo Draize eye test has been criticized for limited predictivity, costs and ethical issues, several animal-free test methods have been developed to categorize ...
Lotz, Christian, Schmid, Freia F., Rossi, Angela, Kurdyn, Szymon, Kampik, Daniel, De Wever, Bart, Walles, Heike, Groeber, Florian K.   +7 more
core   +6 more sources

Eye Irritation Test of Fel Ursi & Bovis Calculus Pharmacopuncture Solutions for Eye Drop

Journal of Pharmacopuncture, 2008
Objective : This study was done to investigate the safety of Fel Ursi & Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods : The eye irritation test of this material was performed according to the
Hyeong-sik Seo
doaj   +2 more sources

Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation [PDF]

, 2022
Art. 15049, 13 S.Highly invasive animal based test procedures for risk assessment such as the Draize eye test are under increasing criticism due to poor transferability for the human organism and animal-welfare concerns. However, besides all efforts, the
Walles, Heike, Schmid, Freia F., Kiesewetter, L., Groeber-Becker, Florian Kai, Hansmann, Jan, Lotz, Christian   +5 more
core   +2 more sources

1,2-propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia. [PDF]

Animal Model Exp Med
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Li X, Chen Y, Xiao X, Xu G.
europepmc   +2 more sources

Preliminary Study on an Alternative Test Method with MCTT HCE^TM for Ocular Irritation Test of Ophthalmic Medical Devices

Toxics, 2023
The sustained growth of the market for ophthalmic medical devices has increased the demand for alternatives to animal testing for the evaluation of eye irritation.
Yang-Jee Kim, Dong-Hyuk Seo, Il-Soo Kim, Mi-Sook Jung, Jin-Young Bae, Moon-Yong Song, Kyung-Seuk Song, Jin-Sik Kim   +7 more
doaj   +1 more source

TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment [PDF]

Iranian Journal of Veterinary Medicine, 2019
Background: The safety evaluations of sunscreens containing Titanium Dioxide-Nanoparticles (TiO2-NPs) were done by dermal exposure, acute dermal and eye irritation/corrosion, and skin sensitization according to the guideline for Organization for Economic
Seyedeh Maedeh Jafari, Goudarz Sadeghi Hashtjin, Mohammad Kazem Koohi, Ali Rasooli, Ebrahim Shahroozian   +4 more
doaj   +1 more source

The clinical effectiveness and cost-effectiveness of second-eye cataract surgery: a systematic review and economic evaluation [PDF]

, 2014
Background: Elective cataract surgery is the most commonly performed surgical procedure in the NHS. In bilateral cataracts, the eye with greatest vision impairment from cataract is operated on first.
Jonathan Shepherd, Frampton, Geoff, Geoff Frampton, Petra Harris, Harris, Petra, Andrew Lotery, Keith Cooper, Cooper, Keith, Shepherd, Jonathan, Lotery, Andrew J.   +9 more
core   +1 more source

Characterization of new eye drops with choline salicylate and assessment of their irritancy by in vitro short time exposure tests

Saudi Pharmaceutical Journal, 2014
The aim of our study was to examine the irritation potential of new eye drops containing 2% choline salicylate (CS) as an active pharmaceutical ingredient (API) and various polymers increasing eye drop viscosity (hydroxyethylcellulose, hydroxypropyl ...
Katarzyna Wroblewska, Małgorzata Kucinska, Marek Murias, Janina Lulek   +3 more
doaj   +1 more source