Results 81 to 90 of about 6,288,832 (388)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization

Pharmaceutics, 2012
Self-Nanoemulsifying Drug Delivery Systems (SNEDDSs) were developed using well-defined excipients with the objective of mimicking digested SNEDDSs without the use of enzymes and in vitro lipolysis models and thereby enabling studies of the morphology and
Anne T. Larsen, Anette Müllertz, Ragheb Abu-Rmaileh, Bertil Abrahamsson, Jesper Østergaard, Anayo Ogbonna   +5 more
doaj   +1 more source

Effect of Frequency on Droplet Characteristics in Ultrasonic Atomization Process [PDF]

E3S Web of Conferences, 2019
The study of ultrasonic atomization is one of the important factors for fuel spray process in the diesel engine combustion chamber. The droplet characteristics are influenced by liquid properties and vibration frequency.
Sugondo Amelia, Sutrisno, Anggono Willyanto, Anne Olga   +3 more
doaj   +1 more source

Broadening of Cloud Droplet Size Distributions by Condensation in Turbulence

Journal of the Meteorological Society of Japan. Ser. II, 2019
To consider the growth of cloud droplets by condensation in turbulence, the Fokker–Planck equation is derived for the droplet size distribution (droplet spectrum).
Izumi Saito, T. Gotoh, Takeshi Watanabe
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Cloud microphysical effects of turbulent mixing and entrainment

, 2012
Turbulent mixing and entrainment at the boundary of a cloud is studied by means of direct numerical simulations that couple the Eulerian description of the turbulent velocity and water vapor fields with a Lagrangian ensemble of cloud water droplets that ...
A. Lanotte, A.B. Kostinski, A.M. Blyth, A.N. Kolmogorov, B. Knaepen, Bipin Kumar, D. Lamb, G. Steinfeld, H. Siebert, J. Latham, J. Schumacher, J. Schumacher, J.B. Jensen, J.P. Mellado, Jörg Schumacher, K. Lehmann, M. Andrejczuk, M. Andrejczuk, M. Andrejczuk, M.B. Baker, P.A. Vaillancourt, R.A. Shaw, R.R. Rogers, Raymond A. Shaw, S. Wang, V. Eswaran   +25 more
core   +1 more source

Large droplet impact on water layers [PDF]

, 2004
The impact of large droplets onto an otherwise undisturbed layer of water is considered. The work, which is motivated primarily with regard to aircraft icing, is to try and help understand the role of splashing on the formation of ice on a wing, in ...
Gueyffier D., Howison S.D., Josserand C., Korobkin A. A., Noh W. F., Purvis R., Purvis R., Rider W. J., Smith F. T., Thoroddson S. T., Worthington A. M.   +10 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Droplet Size Distribution Characteristics of Aerial Nozzles by Bell206L4 Helicopter under Medium and Low Airflow Velocity Wind Tunnel Conditions and Field Verification Test

Applied Sciences, 2020
To investigate the spray atomization characteristics of aerial nozzles adapted to manned agricultural helicopters under medium-low airflow velocity (0 to 27.8 m/s) conditions, the droplet size test was carried out in both wind tunnel and field tests.
Weixiang Yao, Yubin Lan, W. Clint Hoffmann, Jiyu Li, Shuang Guo, Huihui Zhang, Juan Wang   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source