Results 81 to 90 of about 221,845 (303)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Experimental Research on the Atomization Characteristics of Air-Induction Spray Based on Oil-Based Emulsion

Agronomy
Spray drift is one of the major factors that causes pesticide loss and environmental pollution. Air-induction spray is an important anti-drift technology; however, the atomization characteristics of air-induction spray, particularly when the spray liquid
Mingzhi Yan, Fujun Chen, Chen Gong, Can Kang   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Rheology of Highly Concentrated Emulsions – Concentration and Droplet Size Dependencies

Applied Rheology, 2007
The concentration and size dependencies of elastic properties of highly concentrated w/o emulsions were studied. The range of weight concentration of the disperse phase was 90 - 96%, the range of the average droplet size was 16 - 20 mm, and the droplet ...
Masalova Irina, Malkin Alexander Ya.
doaj   +1 more source

Application of Machine Learning Method to Quantitatively Evaluate the Droplet Size and Deposition Distribution of the UAV Spray Nozzle

Applied Sciences, 2020
Unmanned Aerial Vehicle (UAV) spray has been used for efficient and adaptive pesticide applications with its low costs. However, droplet drift is the main problem for UAV spray and will induce pesticide waste and safety concerns.
Han Guo, Jun Zhou, Fei Liu, Yong He, He Huang, Hongyan Wang   +5 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Spectral Differencing of Glories Reflects Cloud Droplet Size Distribution

Geophysical Research Letters
The glory, a striking optical phenomenon seen from space in unpolarized satellite images can be mapped onto the cloud's droplet sizes with a characteristic scale of 10μm.
Ilan Koren, Alex Kostinski, Uri Wollner
doaj   +1 more source

Adaptation of a Cascade Impactor to Flight Measurement of Droplet Size in Clouds [PDF]

A cascade impactor, an instrument for obtaining: the size distribution of droplets borne in a low-velocity air stream, was adapted for flight cloud droplet-size studies.
Kleinknecht, Kenneth S., Levine, Joseph
core   +1 more source