Results 141 to 150 of about 85,546 (299)

Probe‐Free, Primer‐Programmed Amplicon Encoding Enables Nanopore‐Based Multiplex Detection With Deep Learning Decoding

open access: yesAdvanced Science, EarlyView.
Primer‐programmed amplicon encoding enables reporter‐probe‐free multiplex nucleic acid identification using glass nanopore sensing and deep neural network decoding. ABSTRACT Single‐reaction multiplex nucleic acid testing (NATs) must both co‐amplify multiple targets and distinguish the resulting amplicons within the product mixture.
Md. Ahasan Ahamed   +4 more
wiley   +1 more source

An AI‐Driven Framework for Directed Self‐Assembly Toward Design‐Technology Co‐Optimization

open access: yesAdvanced Science, EarlyView.
An artificial intelligence (AI)‐driven closed‐loop framework integrates experiment, three‐dimensional physics‐based simulation, and template design for directed self‐assembly (DSA). Guided by experimental data, AI‐assisted calibration accelerates model optimization, supports morphology prediction, and identifies template windows.
Caiwei Shang   +9 more
wiley   +1 more source

Advances in Josephson Junction Materials and Processes Toward Practical Quantum Computing

open access: yesAdvanced Science, EarlyView.
Emerging materials for quantum computing, including crystalline materials, two‐dimensional van der Waals materials, two‐dimensional electron gas systems, ferromagnets, and unconventional (e.g., d‐wave) superconductors, offer opportunities to engineer next‐generation Josephson junctions.
Hyunseong Kim   +11 more
wiley   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

open access: yesAdvanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao   +5 more
wiley   +1 more source

3′‐UTR Hypermethylation and ABA Signaling Coordinate Transcriptional Activation of SWEET14 for High Sugar Accumulation in Citrus

open access: yesAdvanced Science, EarlyView.
Hypermethylation of CliSWEET14 3′‐UTR relieves ClibHLH105‐mediated transcriptional repression, together with ABA signaling‐mediated activation of the CliABF3‐CliNAC56 cascade, boosts CliSWEET14 expression and sucrose accumulation in citrus. ABSTRACT Sugar accumulation is pivotal for fruit quality, yet the molecular regulation of this process remains ...
Yike Zeng   +13 more
wiley   +1 more source

ReLink: Reliable Deep Learning for Microscopic Motion Tracking

open access: yesAdvanced Science, EarlyView.
ReLink enables reliable trajectory linking in single‐particle tracking by integrating physics‐informed motion statistics with confidence‐based adaptive filtering. Across diverse simulated and experimental conditions, ReLink robustly reconstructs trajectories and preserves the fidelity of downstream analyses, enabling accurate characterization of ...
Yuan Jiang   +7 more
wiley   +1 more source

Factors Influencing Dropouts' GED & Diploma Attainment

open access: yesEducation Policy Analysis Archives, 2001
This study examined correlates of degree attainment in high school dropouts. Participants were high school dropouts of Mexican American or non-Latino white descent who had no degree, a high school degree, or a GED certificate.
Jeffrey C. Wayman
doaj  

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

open access: yesAdvanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song   +5 more
wiley   +1 more source

A Single‐Capillary Open Microfluidic Probe for Robust and Versatile Spatial Multi‐Omics Using Ambient Mass Spectrometry Imaging

open access: yesAdvanced Science, EarlyView.
This study reports a knot‐shaped single‐capillary open microfluidic probe (Knot‐probe) for robust and versatile spatial omics, enabling ambient mass spectrometry imaging with high spatial resolution, throughput, and structure‐resolved capability. Knot‐probe mitigates the trade‐off between analytical performance and operational robustness, providing an ...
Xiangyu Zhu   +10 more
wiley   +1 more source

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