Spatial information matters: are traditional imputation methods effective for spatial transcriptomics data? [PDF]
Brief BioinformHafiz F, Azim R, Shatabda S.
europepmc +1 more source
AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective
Advanced Intelligent Discovery, EarlyView.The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley +1 more source
Trust in medical art is the most effective coping mechanism for predicting treatment satisfaction in elective neurosurgery. [PDF]
Sci RepSchock L +13 more
europepmc +1 more source
AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes
Advanced Intelligent Discovery, EarlyView.To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song +6 more
wiley +1 more source
Enrollment or dropout: dynamics of social health insurance participation among Chinese children and their impact on health service utilization and medical expenses. [PDF]
Health Policy PlanXu J, Coyte PC, Kang Z.
europepmc +1 more source
Machine‐Learning‐Assisted Onset‐Time Determination in Transient Luminescence Thermometry
Advanced Intelligent Discovery, EarlyView.Artificial neural networks enable autonomous extraction of onset times from transient heating curves in luminescence thermometry. Using Ln3+‐doped upconverting nanoparticles as luminescent thermometers, we combine experimental transients with physically motivated synthetic curves to enhance data diversity and improve generalization.
David J. Sousa +3 more
wiley +1 more source
"The one that got away"- therapists' experiences when patients suddenly drop out from psychotherapy: a thematic analysis. [PDF]
BMC PsycholKullgard N +4 more
europepmc +1 more source
Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics
Advanced Intelligent Discovery, EarlyView.A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha +2 more
wiley +1 more source
Response to "comment on a submandibular gland-sparing radiotherapy study: a methodological and analytical perspective". [PDF]
Clin Transl Radiat OncolGarg P +6 more
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.AI‐BioMech is a deep learning framework that predicts the mechanical behavior of biological cellular materials directly from 2D images. By replacing traditional finite element analysis with semantic segmentation, it identifies stress and strain distributions with 99% accuracy, offering a high‐speed, scalable alternative for analyzing complex, aperiodic
Haleema Sadia +2 more
wiley +1 more source