Results 101 to 110 of about 22,218 (269)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Numerical analysis of pantograph–catenary coupling vibration for high-speed railways

AIP Advances
There is a pronounced coupling vibration between the catenary and pantograph during operation for high-speed railways. In this paper, a pantograph–catenary coupling vibration model is constructed to investigate the vibration characteristics under various
Like Pan, Peihuo Peng, Liming Chen, Fan He   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Utilization of boron particulate wall conditioning in the full tungsten environment of WEST

Nuclear Materials and Energy
Over a series of experiments performed on the WEST device we have demonstrated the ability to perform controlled impurity injections and improve overall wall conditions.
R. Lunsford, A. Gallo, Ph. Moreau, A. Diallo, K. Afonin, A. Nagy, F.-P. Pellissier, C. Guillemaut, J.P. Gunn, C. Bourdelle, C. Desgranges, P. Manas, C.C. Klepper, E. Tsitrone, E.A. Unterberg, L. Vermare   +15 more
doaj   +1 more source

Water Quality Monitoring [PDF]

This activity is designed to study the water quality of a stream in your area, by measuring the temperature, pH, alkalinity, conductivity and total dissolved solids.
Charlotte Naples
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Catenary dropper fault identification based on improved FCOS algorithm

Journal of Measurement Science and Instrumentation
The contact network dropper works in a harsh environment, and suffers from the impact effect of pantographs during running of trains, which may lead to faults such as slack and broken of the dropper wire and broken of the current-carrying ring.
GU Guimei, WEN Bokang, JIA Yaohua, ZHANG Cunjun   +3 more
doaj  

BUILDING AND ANALYSIS FOR DYNAMIC SIMULATION MODEL OF CATENARY

Jixie qiangdu, 2020
The catenary of full-compensated simple chain suspension widely used at present china railway was taken as the research object,and a dynamic simulation model of pantograph-catenary was established using the finite element method.
HU Yan, HUANG PanPan
doaj  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source