Results 201 to 210 of about 710,573 (349)

Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD

Developmental Dynamics, EarlyView.
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim, You‐Lim Hwang, Sunwoo Yeom, Seung‐Hae Kwon, Sang‐Hak Jeon   +4 more
wiley   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

Single‐cell sequencing reveals potential novel insights into appendage‐patterning and joint‐development in a spider

Developmental Dynamics, EarlyView.
Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez, Graham E. Budd, Ralf Janssen   +2 more
wiley   +1 more source

Transcriptome-wide regulation of folate on neural mRNA m⁶A methylome via carbon metabolism in Drosophila and mammals. [PDF]

Commun Biol
Liu A, Huo Z, Xu Z, Liu S, Jiao Y, Li R, Lu Y, Yang M, Huang J, Huang C, Wang X.   +10 more
europepmc   +1 more source

Variation and Dominance at the Scute Locus in Drosophila Melanogaster [PDF]

, 1959
J M RENDEL
openalex   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

The Development of a Pupal Lethal Mutant inDrosophila [PDF]

, 1959
H. H. El Shatoury
openalex   +1 more source

The effect of Clitoria ternatea L. flowers-derived silver nanoparticles on A549 and L-132 human cell lines and their antibacterial efficacy in Caenorhabditis elegans in vivo

Hybrid Advances
Clitoria ternatea L. flowers were used for the green synthesis of silver nanoparticles (CT-AgNPs) with a focus on their anticancer and antimicrobial properties. The CT-AgNPs were characterized using a variety of techniques, including UV–Vis spectroscopy,
Sapam Riches Singh, Bushrabanu Kittur, Santosh Mallikarjun Bhavi, Bothe Thokchom, Akshata Choudhari Padti, Shivanand S. Bhat, Sukesh Kumar Bajire, Rajesh P. Shastry, B.S. Srinath, Mika Sillanpää, B.P. Harini, Ramesh Babu Yarajarla   +11 more
doaj  

Drosophila melanogaster as a rapid in vivo assay system for preclinical anti‐seizure medication testing

Epilepsia Open, EarlyView.
Abstract Epilepsy represents a significant medical challenge, with a third of patients failing to achieve seizure freedom despite the use of multiple different anti‐seizure medications (ASM). Drug resistance is common in genetically caused epilepsies. Patients are faced with repeated, long‐lasting, and frequently frustrating drug testing, necessitating
Emma V. Töfflinger, Konstantin L. Makridis, M.‐Marcel Heim, David Owald, Angela M. Kaindl   +4 more
wiley   +1 more source