Results 221 to 230 of about 842,087 (402)

MicroRNA Targets in Drosophila

open access: yesGenome Biology, 2003
Anton J. Enright   +5 more
semanticscholar   +1 more source

A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez   +2 more
wiley   +1 more source

Modularity, Hierarchical Flows and Symmetry of the Drosophila Connectome [PDF]

open access: yesarXiv
This report investigates the modular organisation of the Central region in the Drosophila connectome. We identify groups of neurones amongst which information circulates rapidly before spreading to the rest of the network using Infomap. We find that information flows along pathways linking distant neurones, forming modules that span across the brain ...
arxiv  

A FURTHER ANALYSIS OF LOCI IN THE SO-CALLED "INERT REGION" OF THE X CHROMOSOME OF DROSOPHILA [PDF]

open access: bronze, 1937
Hermann J. Müller   +3 more
openalex   +1 more source

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

open access: yesCell, 2007
Jixin Dong   +9 more
semanticscholar   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum   +2 more
wiley   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner   +7 more
wiley   +1 more source

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