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A connectome and analysis of the adult Drosophila central brain

bioRxiv, 2020
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster.
Louis K. Scheffer +114 more
semanticscholar +1 more source

Acute Exposure to Arsenic Affects Pupal Development and Neurological Functions in Drosophila melanogaster

Toxics, 2023
Millions of people in developing countries are affected by arsenic (As) toxicity and its prevalence. Arsenic’s detrimental effects on humans have been amplified by an unacceptable level of exposure to food and drinking water, the ongoing rise in ...
Anushree +3 more
doaj +1 more source

The genome sequence of Drosophila melanogaster.

Science, 2000
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans.
M. Adams +194 more
semanticscholar +1 more source

The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila [PDF]

, 2018
Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure.
Hartley, Paul S. +3 more
core +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
wiley +1 more source

The host defense of Drosophila melanogaster.

Annual Review of Immunology, 2007
To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense reactions, many of which are shared with higher organisms. These reactions include the use of physical barriers together with local and systemic immune responses.
B. Lemaître, J. Hoffmann
semanticscholar +1 more source

Neural Representations of Courtship Song in the Drosophila Brain [PDF]

, 2012
Acoustic communication in drosophilid flies is based on the production and perception of courtship songs, which facilitate mating. Despite decades of research on courtship songs and behavior in Drosophila, central auditory responses have remained ...
, +4 more
core +2 more sources

Experimental Control and Characterization of Autophagy in Drosophila [PDF]

, 2008
Insects such as the fruit fly Drosophila melanogaster, which fundamentally reorganize their body plan during metamorphosis, make extensive use of autophagy for their normal development and physiology.
A.D. Velentzas +18 more
core +1 more source

The natverse, a versatile toolbox for combining and analysing neuroanatomical data

eLife, 2020
To analyse neuron data at scale, neuroscientists expend substantial effort reading documentation, installing dependencies and moving between analysis and visualisation environments.
Alexander Shakeel Bates +6 more
doaj +1 more source

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

Cell Death and Disease, 2021
Polyglutamine (polyQ) diseases comprise Huntington’s disease and several subtypes of spinocerebellar ataxia, including spinocerebellar ataxia type 3 (SCA3).
Zhefan Stephen Chen +3 more
doaj +1 more source

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