Results 51 to 60 of about 126,952 (258)

Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution [PDF]

, 2011
Here, I merge the principles of synthetic biology^1,2^ and regulatory evolution^3-11^ to create a new species^12-15^ with a minimal set of known elements.
Moreno, Eduardo, Eduardo Moreno
core   +1 more source

The selectivity and specificity of autophagy in drosophila [PDF]

, 2012
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Nezis, I. P., Ioannis P. Nezis
core   +1 more source

A study on the antioxidant, cytotoxicity, and coagulation potential of carbon quantum dots derived from the leaves of Lagerstroemia speciosa

Hybrid Advances
The green synthesis of carbon quantum dots (CQDs) from natural sources offers a sustainable approach in nanotechnology. In this study, CQDs were synthesized from Lagerstroemia speciosa leaves (LS-CQDs) and extensively characterized for their optical ...
Sapam Riches Singh, Gouramma R. Kanamadi, Bothe Thokchom, Santosh Mallikarjun Bhavi, Megha B. Abbigeri, Pooja Joshi, Sudheendra Rao Kulkarni, Akshata Choudhari Padti, B.P. Harini, Ramesh Babu Yarajarla   +9 more
doaj   +1 more source

The natverse, a versatile toolbox for combining and analysing neuroanatomical data

eLife, 2020
To analyse neuron data at scale, neuroscientists expend substantial effort reading documentation, installing dependencies and moving between analysis and visualisation environments.
Alexander Shakeel Bates, James D Manton, Sridhar R Jagannathan, Marta Costa, Philipp Schlegel, Torsten Rohlfing, Gregory SXE Jefferis   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). [PDF]

, 2009
Bacterial and fungal infections induce a potent immune response in Drosophila melanogaster, but it is unclear whether viral infections induce an antiviral immune response.
Carpenter Jennifer, Sarah S. Saminadin-Peter, Jiggins, F., Saminadin-Peter Sarah S., Roller, Julia, John F Baines, Saminadin-Peter, S., Stephan Hutter, Sarah S Saminadin-Peter, Jiggins, Francis M., Roller Julia, Jiggins Francis M., Julia Roller, John F. Baines, John Parsch, Jennifer Carpenter, Parsch, J., Baines, J., Parsch, John, Roller, J., Baines, John F., Francis M. Jiggins, Parsch John, Francis M Jiggins, Sarah S. Saminadin-peter¤a, Saminadin-Peter, Sarah S., Carpenter, J., Jennifer Carpenter, Hutter Stephan, Hutter, S., Hutter, Stephan, Carpenter, Jennifer, Baines John F., Francis M. Jiggins¤b   +33 more
core   +1 more source

Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in Drosophila cells

eLife, 2023
Loss-of-function and gain-of-function genetic perturbations provide valuable insights into gene function. In Drosophila cells, while genome-wide loss-of-function screens have been extensively used to reveal mechanisms of a variety of biological processes,
Baolong Xia, Raghuvir Viswanatha, Yanhui Hu, Stephanie E Mohr, Norbert Perrimon   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content [PDF]

, 2005
Introns comprise a large fraction of eukaryotic genomes, yet little is known about their functional significance. Regulatory elements have been mapped to some introns, though these are believed to account for only a small fraction of genome wide intronic
Haddrill, Penelope R, Halligan, D L, Charlesworth, B, Daniel L Halligan, Haddrill, P R, Peter Andolfatto, Charlesworth, Brian, Brian Charlesworth, Halligan, Daniel L, Penelope R Haddrill, Andolfatto, Peter, Andolfatto, P   +11 more
core   +1 more source