Results 51 to 60 of about 408,842 (307)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). [PDF]

, 2009
Bacterial and fungal infections induce a potent immune response in Drosophila melanogaster, but it is unclear whether viral infections induce an antiviral immune response.
Carpenter Jennifer, Sarah S. Saminadin-Peter, Jiggins, F., Saminadin-Peter Sarah S., Roller, Julia, John F Baines, Saminadin-Peter, S., Stephan Hutter, Sarah S Saminadin-Peter, Jiggins, Francis M., Roller Julia, Jiggins Francis M., Julia Roller, John F. Baines, John Parsch, Jennifer Carpenter, Parsch, J., Baines, J., Parsch, John, Roller, J., Baines, John F., Francis M. Jiggins, Parsch John, Francis M Jiggins, Sarah S. Saminadin-peter¤a, Saminadin-Peter, Sarah S., Carpenter, J., Jennifer Carpenter, Hutter Stephan, Hutter, S., Hutter, Stephan, Carpenter, Jennifer, Baines John F., Francis M. Jiggins¤b   +33 more
core   +1 more source

Drosophila by the dozen [PDF]

Genome Biology, 2007
A report of the 48th Annual Drosophila Research Conference, Philadelphia, USA, 7-11 March 2007.
Celniker, Susan E., Hoskins, Roger A.
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content [PDF]

, 2005
Introns comprise a large fraction of eukaryotic genomes, yet little is known about their functional significance. Regulatory elements have been mapped to some introns, though these are believed to account for only a small fraction of genome wide intronic
Haddrill, Penelope R, Halligan, D L, Charlesworth, B, Daniel L Halligan, Haddrill, P R, Peter Andolfatto, Charlesworth, Brian, Brian Charlesworth, Halligan, Daniel L, Penelope R Haddrill, Andolfatto, Peter, Andolfatto, P   +11 more
core   +1 more source

Drosophila myogenesis [PDF]

Current Biology, 2016
The skeletal muscle system is the largest organ in motile animals, constituting between 35 and 55% of the human body mass, and up to 75% of the body mass in flying organisms like Drosophila. The flight muscles alone in flying insects comprise up to 65% of total body mass.
Ingo, Bothe, Mary K, Baylies
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A novel insertional allele of the CG18135 gene is associated with severe mutant phenotypes in Drosophila melanogaster

Frontiers in Genetics
Drosophila melanogaster has been at the forefront of genetic studies and biochemical modeling for over a century. Yet, the functions of many genes are still unknown, mainly because no phenotypic data are available.
Attila Cristian Ratiu, Attila Cristian Ratiu, Adrian Ionascu, Adrian Ionascu, Alexandru Al. Ecovoiu   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source