Results 141 to 150 of about 280,859 (262)

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

First genomic analysis of Platycopioida and phylogenomics across six copepod orders

Cladistics, EarlyView.
Abstract Recent advances in bioinformatics have significantly expanded our understanding of the genetic properties of organisms and have provided valuable insights into their phylogenetic relationships and evolutionary histories. However, molecular phylogenetic studies of the class Copepoda remain limited, and the focus has been mainly on the major ...
Donggu Jeon, Chi‐une Song, Junil Ko, Yusuke Kondo, Kenji Toyota, Man‐Ki Jeong, Ho Young Soh, Susumu Ohtsuka, Seong‐il Eyun   +8 more
wiley   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Two Metschnikowia nectar yeast species have similar volatile profiles but elicit differential foraging in bee pollinators

Ecological Entomology, EarlyView.
Yeasts that specialize in flower nectar play an important role in pollination ecology. Metschnikowia reukaufii and Metschnikowia koreensis were the most prevalent nectar yeasts found in our field sites. Bee pollinators exhibited different behavioural responses to nectar yeasts in field experiments. Bees visited more flowers with M.
M. Elizabeth Moore, Lindsey Wilson, Nathan Brandt, Ayako Wada‐Katsumata, Ahmed M. Saveer, Coby Schal, Robert R. Dunn, Rebecca E. Irwin, Caiti Smukowski Heil   +8 more
wiley   +1 more source

Drosophila Melanogaster as a Model for Molybdo-Flavoenzyme Mediated Protection against Chemical and Physical Stress [PDF]

Aldehyde oxidase (AO) and xanthine oxidoreductase (XOR) are molybdo-flavoenzymes (MFEs) involved in the oxidation of hundreds of endogenous and exogenous aldehydes and N-heterocyclic compounds many of which are drugs, vitamins and environmental ...
Al Salhen, Khaled S
core   +1 more source

Fungal infection affects sexual signalling and mate choice in the sugarcane borer

Ecological Entomology, EarlyView.
Fungus‐infected Diatraea saccharalis females exhibit enhanced attractiveness to males in wind tunnel assays. Fungal infection alters the pheromone profile of females, increasing the relative abundance of Z9‐16: Ald, a minor but behaviourally active component of the species' sex pheromone blend.
Amanda C. Tuler, Arodi P. Favaris, Flávia P. Franco, José Mauricio S. Bento   +3 more
wiley   +1 more source

Selective feeding and niche differentiation in adult boreal Odonata revealed by DNA metabarcoding

Ecological Entomology, EarlyView.
COI metabarcoding of faecal pellets from three sympatric Odonata species in boreal Swedish wetlands revealed Diptera‐dominated diets, with mosquitoes only a minor component despite high availability. The larger hawker Libellula quadrimaculata showed greater dietary variance than the smaller damselflies, indicating size‐ and foraging strategy‐dependent ...
Hana N. Merchant, Anssi Laurila, Eero J. Vesterinen, Jan O. Lundström, Frank Johansson   +4 more
wiley   +1 more source

A genetic model of copulatory wounding in Drosophila melanogaster. [PDF]

Genetics
Jalkut SL, Bischoff LM, Pitsch MJ, Losick VP.   +3 more
europepmc   +1 more source

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding

The FEBS Journal, EarlyView.
Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh, Charlene Y. P. Guerrero, Madelyn R. Cusick, Amanda J. Samaras, Taylor M. Stephenson, Sebastian L. Kirkpatrick, Gregory J. Matthews, Daniel J. Cavanaugh   +7 more
wiley   +1 more source

The fruitfly Drosophila melanogaster as an in vivo model of ferroptosis. [PDF]

Redox Biol
Zhang L, Schmidt F, Yasar F, Akele Y, Michalke B, Beckschäfer K, Thiele C, Hanschmann EM, Venkataramani V, Methner A.   +9 more
europepmc   +1 more source