Results 161 to 170 of about 5,995,584 (403)

In vivo Hox binding specificity revealed by systematic changes to a single cis regulatory module

open access: yesNature Communications, 2019
Hox proteins are expressed in partially overlapping regions to inform development along the embryo’s head-tail axis. Here the authors analyse a cis regulatory module directly regulated by seven different Drosophila Hox proteins to uncover how different ...
Carlos Sánchez-Higueras   +5 more
doaj   +1 more source

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

open access: yesCell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio   +6 more
wiley   +1 more source

Hydrophobic and Polarized Aromatic Residues Promote Internalization of Arg‐Rich Cell‐Penetrating Peptides through Ionpair‐π Interactions

open access: yesChemistry – A European Journal, EarlyView.
By introducing analogues of Trp in Ar/Trp cell‐penetrating peptides, we investigated the role of this unique amino acid in the cell uptake and interaction with cell membrane partners using experimental and computational approaches. Abstract Cell penetrating peptides (CPPs) are small sequences that can cross cell membranes.
Sonia Khemaissa   +6 more
wiley   +1 more source

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

open access: yesCytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou   +6 more
wiley   +1 more source

Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax.

open access: yesPLoS Genetics
Hox proteins, a sub-group of the homeodomain (HD) transcription factor family, provide positional information for axial patterning in development and evolution.
Jesús R Curt   +9 more
doaj   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

open access: yesCytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah   +2 more
wiley   +1 more source

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