Results 101 to 110 of about 400,933 (233)

Dynamic Interfacial Chemistry of Choline Chloride as Electrolyte Additive for Stable Zn‐Iodine Batteries

Advanced Functional Materials, EarlyView.
Choline chloride (ChCl) additive enables dynamic interface engineering in Zn‐I2 batteries by forming hydrophobic polyiodide complexes and a Zn‐stabilizing Ch+‐rich layer under electric field modulation. This dual‐function strategy suppresses iodine hydrolysis and dendrite formation, while optimizing Zn2+ solvation and transport for high‐efficiency ...
Xiaoyu Bi, Yuchuan Ren, Ao Yu, Linlin Yang, Ren He, Yapeng Cheng, Xingqi Chang, Xuan Lu, Yanting Xie, Qian Xue, Hu Yuan, Canhuang Li, Runzhou Huang, Jordi Jacas Biendicho, Chaoqi Zhang, Jian Shang, Andreu Cabot   +16 more
wiley   +1 more source

Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase

, 2018
The rise of antibiotic resistance has created a mounting crisis across the globe and an unmet medical need for new antibiotics. As part of our efforts to develop new antibiotics to target the uncharted surface bacterial transglycosylase, we report an ...
Chi-Huey Wong (63704), Wei-Chieh Cheng (1335870), Wei-Shen Wu (1885708), Ting-Jen R. Cheng (1711648)   +3 more
core   +1 more source

A Molecular Shielding Strategy to Develop Low Protein Binding, Renal Clearable Pan‐Cancer Near‐Infrared Probes

Advanced Functional Materials, EarlyView.
A molecular shielding strategy to convert “protein‐sticky” and “non‐tumor specific” clinical ICG dye, into a “low protein binding” and “tumor‐targeting” dye with prolonged blood circulation and renal clearance is described. These shielded ICGs demonstrate strong tumor accumulation and optimal tissue clearance, resulting in high tumor‐to‐background ...
Li Xiang, Kailin Mooney, Mingchong Dai, Morgan R. Stewart, Samantha Holland, Michael I. Henderson, Samuel Drennan, Ramon F. Barajas Jr., Jared M. Fischer, Adem Yildirim   +9 more
wiley   +1 more source

Studies and analysis of drug-target interactions by affinity chromatography and related techniques: A review

Journal of Pharmaceutical Analysis
The characterization of drug-target interactions is a key component of drug discovery, testing, and development. Affinity chromatography is one approach that can be used for this type of analysis.
David S. Hage, Sadia Sharmeen, B.K. Sajeeb, Harshana Olupathage, Md Masudur Rahman, Isaac Kyei, Samiul Alim, Nigar Sultana Pinky   +7 more
doaj   +1 more source

Structure-based in silico design of ahigh-affinity dipeptide inhibitor for novel protein drug target Shikimate Kinase of Mycobacterium tuberculosis

, 2010
Tuberculosis remains one of the most dreaded infectious diseases notwithstanding the availability of a number of anti-tuberculosis drugs. The recent rise of multidrug-resistant tuberculosis and its association with HIV infection poses a challenging ...
Kaur, Punit, Sujata Sharma, Manoj Kumar, Tej P. Singh, Sharma, Sujata, Srinivasan, Alagiri, Kumar, Manoj, Alagiri Srinivasan, Verma, Shikha, Singh, Tej P., Singh, Tej P, Punit Kaur, Shikha Verma   +12 more
core   +1 more source

A Dual‐Functional Electrolyte Additive for Highly Reversible Zinc‐Ion Batteries

Advanced Functional Materials, EarlyView.
This study introduces tetrabutylammonium bromide (TBAB) as a dual‐function additive for aqueous zinc‐ion batteries. TBAB disrupts the hydrogen‐bond network of water while TBA+ adsorbs on Zn to improve interfacial wettability and regulate Zn2+ flux, resulting in suppressed dendrite growth and parasitic reactions. This synergy extended the lifespan of Zn|
Shirui Zhang, Shixun Wang, Jianen Zhang, Jun Liu, Jinfeng Xie, Wentao Tang, Li Guan, He Huang, Qi Xue, Chunyi Zhi   +9 more
wiley   +1 more source

Affinity-Based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors

, 2019
Affinity-based protein profiling has proven to be a powerful method in target identification of bioactive molecules. Here, this technology was applied in two photoreactive anticancer inhibitors, arenobufagin and HM30181.
Zhi-Min Zhang (848852), Zhengqiu Li, Nan Ma (314032), Ligen Lin, Dong-Mei Zhang, Piliang Hao, Wen-Cai Ye, Piliang Hao (230313), Ke Ding (309244), Zhengqiu Li (1777864), Jun-Seok Lee (181420), Ke Cheng (161778), Jun-Seok Lee, Dong-Mei Zhang (303527), Ligen Lin (231884), Ke Ding, Wen-Cai Ye (303536), Nan Ma, Ke Cheng, Zhi-Min Zhang   +19 more
core   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

GraphPrint: Extracting Features from 3D Protein Structure for Drug Target Affinity Prediction

Accurate drug target affinity prediction can improve drug candidate selection, accelerate the drug discovery process, and reduce drug production costs. Previous work focused on traditional fingerprints or used features extracted based on the amino acid ...
Singh, Amritpal
core