Results 121 to 130 of about 342,372 (241)

Nanoparticle-Mediated Measurement of Target–Drug Binding in Cancer Cells

, 2016
Responses to molecularly targeted therapies can be highly variable and depend on mutations, fluctuations in target protein levels in individual cells, and drug delivery.
Hakho Lee (372660), Katherine S. Yang (483006), Thomas Reiner (1326930), David Issadore (2134822), Rostic Gorbatov (172533), Adeeti V. Ullal (2144869), Changwook Min (2050462), Ralph Weissleder (60)   +7 more
core   +1 more source

Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance

Advanced Healthcare Materials, EarlyView.
Single‐chain nanoparticles have been proposed as drug delivery carriers, but adding a tail can significantly enhance their performance. This was demonstrated using a tadpole‐like structure comprising a head prepared from a UV‐crosslinked fructose‐based glycopolymer capable of targeting GLUT receptors, combined with a PEG‐based tail. Compared with other
Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel   +6 more
wiley   +1 more source

Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells

, 2019
Responses to molecularly targeted therapies can be highly variable and depend on mutations, fluctuations in target protein levels In individual cells, and drug delivery.
Ullal, Adeeti V., Yang, Katherine S., Weissleder, Ralph, Gorbatov, Rostic, Lee, Hakho, Reiner, Thomas, Min, Changwook, Issadore, David   +7 more
core   +1 more source

Binding Affinity Prediction for Pancreatic Ductal Adenocarcinoma Using Drug-Target Descriptors and Artificial Intelligence

IEEE Access
Pancreatic ductal adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer, accounting for 90% of all pancreatic malignancies.
Pragya, A. Amalin Prince, Jac Fredo Agastinose Ronickom   +2 more
doaj   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

An albumin-derived peptide scaffold capable of binding and catalysis

, 2012
We have identified a 101-amino-acid polypeptide derived from the sequence surrounding the IIA binding site of human albumin. The polypeptide contains residues that make contact with ligands as warfarin in the parent protein, and eight cysteine residues ...
SBLATTERO, DANIELE, Fabio Benedetti, Giampaolo Fontanive (381542), SGARRA, RICCARDO, Daniele Sblattero (251886), Riccardo Sgarra (103906), Immacolata Luisi (381540), MAURIZIO, ELISA, Silvia Pavan (381541), Fabio Benedetti (243799), BENEDETTI, FABIO, Adriano Savoini, LUISI, Immacolata, Alessandro Tossi, Federico Berti, Immacolata Luisi, FONTANIVE, GIAMPAOLO, Silvia Pavan, Federico Berti (381545), BERTI, FEDERICO, Alessandro Tossi (381543), Elisa Maurizio, Ro Tossi, Adriano Savoini (381544), TOSSI, ALESSANDRO, Daniele Sblattero, Savoini A., PAVAN, SILVIA, Riccardo Sgarra, Elisa Maurizio (103901), Giampaolo Fontanive   +30 more
core   +1 more source

ArkDTA: attention regularization guided by non-covalent interactions for explainable drug-target binding affinity prediction. [PDF]

Bioinformatics, 2023
Gim M, Choe J, Baek S, Park J, Lee C, Ju M, Lee S, Kang J.   +7 more
europepmc   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Multivalent sialic acid binding proteins as novel therapeutics for influenza and parainfluenza infection

, 2014
In nature, proteins with weak binding affinity often use a multivalency approach to enhance protein affinity via an avidity effect. Interested in this multivalency approach, we have isolated a carbohydrate binding module (CBM) that recognises sialic ...
Alias, Nadiawati
core  

Improving the Accuracy of Protein-Ligand Binding Affinity Prediction by Deep Learning Models: Benchmark and Model

, 2019
Introduction: The ability to discriminate among ligands binding to the same protein target in terms of their relative binding affinity lies at the heart of structure-based drug design.
Mohammad, Rezaei, Chenglong, Li, Yanjun, Li, Xiaolin, Li   +3 more
core   +1 more source