Advanced Science, EarlyView.Photocatalytic treatment of glyphosate herbicide in agricultural wastewater is achieved through the cooperative effect of the local polarization field and dipole field mediated by lattice‐distorted carbon nitride. Glyphosate is completely degraded via selective C─P bond cleavage with a CO evolution rate of 1166 µmol g−1 h−1.
Daoping Chen +7 more
wiley +1 more source
Drug Safety Assessment Based on Target Affinity, Drug Exposure and Plasma Protein Binding: Drug-Induced Cardiotoxicity from a Translational Pharmacology Perspective. [PDF]
Int J Mol SciCatozzi S +11 more
europepmc +1 more source
Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, EarlyView.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
DrugForm-TAS: Target-Agnostic Selectivity as Proteome-wide Binding Propensity Estimation. [PDF]
Comput Struct Biotechnol JTashchilova A +9 more
europepmc +1 more source
A multi-target drug design method based on target feature fusion. [PDF]
BMC BioinformaticsLiu H, Lin X, Hu J, Zhang X.
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Biophysical Sensing Tools in Drug Discovery: Integrating Kinetics, Thermodynamics, Cellular Target Engagement and Structure. [PDF]
Sensors (Basel)Balıkçı E, Akıl C.
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Advancing Drug Discovery with AI: Machine and Deep Learning Strategies for Target Identification and Precision Nanomedicine. [PDF]
Int J NanomedicineChakraborty A +7 more
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Investigation of metformin analogues in targeting signaling molecules of head and neck cancer pathways by computational approaches. [PDF]
Sci RepArora P +7 more
europepmc +1 more source