Results 211 to 220 of about 522,643 (238)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

BA-Pred and RMSD-Pred: Integrated Graph Neural Network Models for Accurate Protein-Ligand Binding Affinity and Binding Pose Prediction. [PDF]

J Chem Inf Model
Sim J, Lee J.
europepmc   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Exploring potential phytocompounds from black cumin as drug molecules against SARS-CoV-2 infections through bioinformatics analysis. [PDF]

PLoS One
Ali MA, Sheikh H, Reza MS, Paul TR, Noor T, Kumar N, Bhat MA, Mollah MNH.   +7 more
europepmc   +1 more source

KANPM-DTA: improving drug-target affinity prediction with Kolmogorov-Arnold networks and pretrained models. [PDF]

Brief Bioinform
Rakib MDYK, Alamin MH, Li J, Mamun SS, Gobena KA, Ren S.   +5 more
europepmc   +1 more source

Leveraging conformational ensembles in allosteric drug discovery. [PDF]

Trends Pharmacol Sci
Nussinov R, Regev C, Jang H.
europepmc   +1 more source

Multidisciplinary cutting-edge technologies accelerating target-based drug discovery. [PDF]

J Pharm Anal
Li Y, Moaddel R, Jiang Z, Chen X.
europepmc   +1 more source

Application of Reinforcement Learning Techniques in De Novo Drug Design: A Systematic Literature Review. [PDF]

Health Sci Rep
Sampa MB, Aziz NHA.
europepmc   +1 more source

Licochalcone A as a Potential Anti-<i>Toxoplasma</i> Agent: A Target Identification and Pharmacokinetic Study. [PDF]

Biomolecules
Li B, Tao Z, Jing Y, Bai Y, Wang W, Zhai B, Abd El-Aty AM, Zhang C, Zhang J, Hu F.   +9 more
europepmc   +1 more source