Results 91 to 100 of about 5,634,975 (396)

Predicting drug–drug interactions through drug structural similarities and interaction networks incorporating pharmacokinetics and pharmacodynamics knowledge

Journal of Cheminformatics, 2017
Drug–drug interactions (DDIs) may lead to adverse effects and potentially result in drug withdrawal from the market. Predicting DDIs during drug development would help reduce development costs and time by rigorous evaluation of drug candidates.
Takako Takeda, Ming Hao, Tiejun Cheng, S. Bryant, Yanli Wang   +4 more
semanticscholar   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Drug-Drug Interactions at Organic Cation Transporter 1

Frontiers in Pharmacology, 2021
The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays
Shiwei Zhou, Shiwei Zhou, Shiwei Zhou, Sujuan Zeng, Yan Shu, Yan Shu   +5 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]

, 2019
Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E., Chan, Jinyan, Gu, Jinghua, Turner, Jacob A., Wang, Xuan   +4 more
core   +1 more source

Multiscale modelling of cancer progression and treatment control : the role of intracellular heterogeneities in chemotherapy treatment [PDF]

, 2015
Cancer is a complex, multiscale process involving interactions at intracellular, intercellular and tissue scales that are in turn susceptible to microenvironmental changes.
Chaplain, Mark Andrew Joseph, Powathil, Gibin   +1 more
core   +1 more source

Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]

, 2020
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham, Chen, Xing, Nikolakakis, Ioannis, Partheniadis, Ioannis   +3 more
core   +1 more source

Herbal - Synthetic Drug Interactions

Magna Medika, 2023
Background:  Herbal medicine is currently one of the therapeutic options chosen by the community because it is considered relatively safer and has minimal side effects.
Kintoko Kintoko, Aghnia Nabila Ananda, Anisa Rifka Ridho, Annisa Camellia Makati, Asti Afrida Yanti, Dina Wahyuni, Yolanda Sajjida Maghfirah, Isnaini Isnaini   +7 more
doaj   +1 more source

Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital

Journal of Aging Research, 2018
Background and Objectives The drugs most commonly implicated in major potential interactions are those used in the day-to-day clinical management of elderly patients with chronic diseases.
Varsha M Shetty, M. Chowta, Nithyananda Chowta K, A. Shenoy, A. Kamath, P. Kamath   +5 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source