Results 161 to 170 of about 5,634,975 (396)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Drug Interaction [PDF]

, 1968
AE Kessell
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Potential drug-drug interactions and adverse drug reactions in patients with liver cirrhosis [PDF]

, 2018
Background and aims: Patients with liver cirrhosis may be at risk for potential drug-drug interactions (pDDIs) and/or adverse drug reactions (ADRs) due to the severity of their disease and comorbidities associated with polypharmacy. Methods: We performed
Born, Christa, Egger, Sabin, Franz, Carmen, Krähenbühl, Stephan, Rätz Bravo, Alexandra   +4 more
core  

Prevalence of Potential Drug-drug Interactions among Psychiatric Patients at Psychiatry Hospital in Sulaimani City

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Background: Clinically significant drug-drug interactions can be defined as events in which the pharmacodynamics or pharmacokinetic characteristics of a drug are modified by coadministration of a second drug to the patient’s medication protocol, which ...
Raz Muhammed HamaSalih, Rebwar Ghareeb Hama, Sabir Hamid, Pavel Jalal Hussein, Sham Nawshirwan Salh   +4 more
doaj   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Potensi Interaksi Obat Pada Pasien Asma Rawat Inap Di Rsud Dr. Moewardi Tahun 2014 [PDF]

, 2016
Asthma is one of the biggest causes of morbidity and mortality in the world. Treatment of asthma in some patiens has not shown results optimally. The aim of this study was to describe about potential drug interactions in patients hospitalized with asthma
, Nurul Mutmainah, M.Si., Apt., Setyorini, Nurita   +1 more
core  

Nurses' Awareness and Perception of Drug-Drug and Drug Food Interactions

Evidence-Based Nursing Research
Context: The issue of drug interactions is a global concern. Studies reported a high prevalence of drug interactions worldwide. The drug-drug interaction (DDIs) and drug-food interactions (DFIs) are often predictable and preventable.
Hend A. E. Elshenawi, Yasmin F. M. Abed Elazeem   +1 more
doaj   +1 more source

Adverse Drug Interactions [PDF]

, 1972
S K Bhattacharya
openalex   +1 more source