Results 201 to 210 of about 1,945,844 (251)

Drug–Drug Interactions

2018
A drug interaction occurs when the effects of a drug are altered by the effects of another drug, a vaccine, herb, foodstuff, or device. In drug–drug interactions, a precipitant drug increases or reduces the effects of an object drug by pharmaceutical, pharmacokinetic, or pharmacodynamic mechanisms.
Mathew George, Lincy Joseph, Sujith K
  +6 more sources

CARDIOVASCULAR DRUG-DRUG INTERACTIONS

Cardiology Clinics, 2001
The drug-drug interactions discussed in this article have either documented or suspected clinical relevance for patients with cardiovascular disease and the clinician involved in the care of these patients. Oftentimes, drug-drug interactions are difficult, if not impossible, to predict because of the high degree of interpatient variability in drug ...
J R, Anderson, J J, Nawarskas
openaire   +2 more sources

Drug–drug interaction with statins

Expert Review of Clinical Pharmacology, 2008
3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors (the so-called statins: atorvastatin, fluvastatin, pravastatin, lovastatin, rosuvastatin and simvastatin) are a well-established class of drugs in the treatment of hypercholesterolemia. Statin monotherapy is generally well tolerated, with a low frequency of adverse events.
A. Corsini, S. Bellosta
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Avoiding Drug-Drug Interactions

Chemotherapy, 2009
<i>Background:</i> Drugs may be prescribed in combinations causing drug-drug interactions (DDI) and adverse drug reactions (ADR), resulting in hospital care. <i>Methods:</i> To provide prescribers of drug therapy with a better knowledge of individuals’ current drug therapy, governments have started to collect prescribing data ...
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Transporter-Mediated Drug–Drug Interactions

Clinical Pharmacology & Therapeutics, 2011
Transporters are membrane-bound proteins that control the access of endogenous and xenobiotics (drugs) to various sites in the human body. They influence drug pharmacokinetics and pharmacodynamics (both benefit and risk) by affecting a drug's absorption, distribution, metabolism (via control of access to metabolizing enzymes), and excretion (ADME) and ...
L, Zhang, S-M, Huang, L J, Lesko
openaire   +4 more sources

Drug–Drug Interaction Prediction Assessment

Journal of Biopharmaceutical Statistics, 2009
Model-based drug-drug interaction (DDI) is an important in-silico tool to assess the in vivo consequences of in vitro DDI. Before its general application to new drug compounds, the DDI model is always established from known interaction data. For the first time, tests for difference and equivalent tests are implemented to compare reported and model-base
Jihao, Zhou, Zhaohui, Qin, Quinney K, Sara, Seongho, Kim, Zhiping, Wang, Stephen D, Hall, Lang, Li   +6 more
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Drug-Drug Interaction

JAMA: The Journal of the American Medical Association, 1969
Interference With the Delivery of Drugs to Their Sites of Action An increasing number of mechanisms have been described whereby one drug can modify profoundly the action of another. In some of these interactions, the therapeutic effect of a drug may be blocked when another agent prevents it from reaching the site of its pharmacologic action ...
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Predicting inductive drug–drug interactions

Pharmacogenomics, 2003
Until recently, inductive drug-drug interactions have proved difficult to predict prior to formal pharmacokinetic studies in man. Even then, important interactions have often gone unrecognized until clinical sequelae have occurred in the postmarketing phase.
Christopher, Liddle, Graham R, Robertson
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