Results 211 to 220 of about 5,634,975 (396)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Interaction of benzodiazepine drugs with striatal dopaminergic neurons in the brain

, 1976
Kazuo Nakamura, Keiji Nakamura
openalex   +1 more source

Interaction between Doxycycline and some Antiepileptic Drugs [PDF]

, 1974
O. Penttilä, Pertti J. Neuvonen, Kimmo Aho, R. Lehtovaara   +3 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

CYP2C8-Mediated Drug-Drug Interactions and the Factors Influencing the Interaction Magnitude. [PDF]

Drug Des Devel Ther
Zhu LL, Yu LY, Wang YH, Zhou Q.
europepmc   +1 more source

The effect of ethanol on drug oxidations in vitro and the significance of ethanol–cytochrome P-450 interaction [PDF]

, 1973
Dominick L. Cinti, Robert Grundin, Sten Orrenius   +2 more
openalex   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Evaluation of in vitro drug-drug interactions of ivermectin and antimalarial compounds. [PDF]

Malar J
Tipthara P, Kullasakboonsri R, Kobylinski KC, Tarning J.   +3 more
europepmc   +1 more source

Interactions Between Clonidine and α-Adrenoceptor Blocking Drugs on the Tachycardic Response to Stimulation of the Cardiac Nerve in Dogs

, 1979
P Mouillé, Anne‐Marie Huchet, Bernadette Lucet, Jacques E. Chelly, Henri Schmitt   +4 more
openalex   +1 more source

Drug Interactions in Patients on Long-term Oral Anticoagulant and Antihypertensive Adrenergic Neuron-blocking Drugs [PDF]

, 1972
Kate J. Starr, J C Petrie
openalex   +1 more source