Results 271 to 280 of about 5,634,975 (396)

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

open access: yesFEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li   +5 more
wiley   +1 more source

Clinical Pharmacology of Bulevirtide: Focus on Known and Potential Drug-Drug Interactions. [PDF]

open access: yesPharmaceutics
Billi M   +4 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Can large language models detect drug-drug interactions leading to adverse drug reactions? [PDF]

open access: yesTher Adv Drug Saf
Sicard J   +9 more
europepmc   +1 more source

Drug-Drug Interactions in Melanoma

open access: yesJournal of the Advanced Practitioner in Oncology, 2018
Bcps   +4 more
openaire   +1 more source

Computational prediction of drug-drug interactions based on drugs functional similarities

open access: yesJournal of Biomedical Informatics, 2017
Reza Ferdousi, R. Safdari, Y. Omidi
semanticscholar   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

open access: yesFEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

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