Results 1 to 10 of about 10,944,767 (389)

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol

open access: yesMolecules, 2022
More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive.
Qianru Rao   +10 more
doaj   +1 more source

Metabolic Profile of C-Prenyl Coumarins Using Mass Spectrometry-Based Metabolomics

open access: yesMolecules, 2021
C-prenyl coumarins (C-PYCs) are compounds with similar structures and various bioactivities, which are widely distributed in medicinal plants. Until now, the metabolic characterizations of C-PYCs and the relationship between metabolism and bioactivities ...
Yan Cheng   +5 more
doaj   +1 more source

Drug-induced uveitis [PDF]

open access: yesJournal of Ophthalmic Inflammation and Infection, 2013
A number of medications have been associated with uveitis. This review highlights both well-established and recently reported systemic, topical, intraocular, and vaccine-associated causes of drug-induced uveitis, and assigns a quantitative score to each medication based upon criteria originally described by Naranjo and associates.
Sunir J. Garg   +5 more
openaire   +4 more sources

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

open access: yesNature Communications, 2023
Parabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P.
Qi Zhao   +12 more
doaj   +1 more source

Clinical Outcome and Risk Assessment in Hospitalized COVID-19 Patients with Elevated Transaminases and Acute Kidney Injury: A Single Center Study

open access: yesOman Medical Journal, 2022
Objectives: Initial reports indicate a high incidence of abnormal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in patients with COVID-19 and possible association with acute kidney injury (AKI).
Yulia Khruleva   +9 more
doaj   +1 more source

Drug-induced pigmentation

open access: yesPigment International, 2022
Around 10% to 20% of all cases of acquired hyperpigmentation are drug-induced. The underlying pathogenesis for drug-induced pigmentation includes melanin accumulation, drug accumulation, toxic effects on melanocytes, and hypersecretion of ...
Arunachalam Narayanan   +1 more
doaj   +1 more source

Drug-induced nephrotoxicity [PDF]

open access: yesRevista da Associação Médica Brasileira, 2020
SUMMARY Acute kidney injury is a very common diagnosis, present in up to 60% of critical patients, and its third main cause is drug toxicity. Nephrotoxicity can be defined as any renal injury caused directly or indirectly by medications, with acute renal failure, tubulopathies, and glomerulopathies as common clinical presentations.
Gabriel Teixeira Montezuma Sales   +1 more
openaire   +4 more sources

Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis

open access: yesBMC Medical Genetics, 2020
Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Current studies have shown that PNPLA3 (Patatin-like phospholipase domain containing 3) rs738409 G/C gene polymorphism is associated ...
Shan Tang   +13 more
doaj   +1 more source

Ceftriaxone-induced acute cholecystitis

open access: yesJournal of Medical Ultrasound, 2021
Ceftriaxone has been increasingly used in pediatric population, due to its bacteriological and pharmacokinetic features. Association between ceftriaxone and biliary sludge/pseudolithiasis formation has been documented in the literature.
Fernanda Marta Gomes   +3 more
doaj   +1 more source

Drug-Induced Parkinsonism [PDF]

open access: yesJournal of Clinical Neurology, 2012
Drug-induced parkinsonism (DIP) is the second-most-common etiology of parkinsonism in the elderly after Parkinson's disease (PD). Many patients with DIP may be misdiagnosed with PD because the clinical features of these two conditions are indistinguishable.
Hae-Won Shin, Sun Ju Chung
openaire   +3 more sources

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