Results 1 to 10 of about 1,413,692 (298)

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol

open access: yesMolecules, 2022
More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive.
Qianru Rao   +10 more
doaj   +1 more source

Metabolic Profile of C-Prenyl Coumarins Using Mass Spectrometry-Based Metabolomics

open access: yesMolecules, 2021
C-prenyl coumarins (C-PYCs) are compounds with similar structures and various bioactivities, which are widely distributed in medicinal plants. Until now, the metabolic characterizations of C-PYCs and the relationship between metabolism and bioactivities ...
Yan Cheng   +5 more
doaj   +1 more source

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

open access: yesNature Communications, 2023
Parabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P.
Qi Zhao   +12 more
doaj   +1 more source

Ceftriaxone-induced acute cholecystitis

open access: yesJournal of Medical Ultrasound, 2021
Ceftriaxone has been increasingly used in pediatric population, due to its bacteriological and pharmacokinetic features. Association between ceftriaxone and biliary sludge/pseudolithiasis formation has been documented in the literature.
Fernanda Marta Gomes   +3 more
doaj   +1 more source

Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis

open access: yesBMC Medical Genetics, 2020
Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Current studies have shown that PNPLA3 (Patatin-like phospholipase domain containing 3) rs738409 G/C gene polymorphism is associated ...
Shan Tang   +13 more
doaj   +1 more source

Clinical Outcome and Risk Assessment in Hospitalized COVID-19 Patients with Elevated Transaminases and Acute Kidney Injury: A Single Center Study

open access: yesOman Medical Journal, 2022
Objectives: Initial reports indicate a high incidence of abnormal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in patients with COVID-19 and possible association with acute kidney injury (AKI).
Yulia Khruleva   +9 more
doaj   +1 more source

Drug-induced pigmentation

open access: yesPigment International, 2022
Around 10% to 20% of all cases of acquired hyperpigmentation are drug-induced. The underlying pathogenesis for drug-induced pigmentation includes melanin accumulation, drug accumulation, toxic effects on melanocytes, and hypersecretion of ...
Arunachalam Narayanan   +1 more
doaj   +1 more source

Clozapine-Induced Pneumonitis: A Case Report

open access: yesFrontiers in Psychiatry, 2020
Introduction: Clozapine is the most effective antipsychotic used for treatment resistant schizophrenia and recurrent suicidal behavior in schizophrenia or schizoaffective disorder.
Tyler Torrico   +3 more
doaj   +1 more source

Phenytoin-associated movement disorder: A literature review

open access: yesTzu Chi Medical Journal, 2022
Phenytoin (PHT) was first synthesized as a barbiturate derivative and was approved in 1953 by the Food and Drug Administration. This work aimed to review the pathophysiology, epidemiology, clinical presentation, and treatment of PHT-associated movement ...
Jamir Pitton Rissardo   +1 more
doaj   +1 more source

Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis

open access: yesBMC Cancer, 2019
Background Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with discrepant conclusions reached.
Shan Tang   +13 more
doaj   +1 more source

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