Results 181 to 190 of about 1,693,725 (358)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Anti-Tubercular Drug-Induced Liver Injury: Current Understanding and Emerging Directions. [PDF]

JGH Open
Prasad S, Narang H, Kedia S, Ahuja V.
europepmc   +1 more source

Transcriptomic signature for drug-induced steatosis [PDF]

, 2015
Stoeber, Regina
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Correction: Comprehensive biomarker analysis of metabolomics in different syndromes in traditional Chinese medical for prediabetes mellitus

Chinese Medicine
Qin Lan, Xue Li, Jianhe Fang, Xinyu Yu, Zhanxuan E. Wu, Caiyun Yang, Hui Jian, Fei Li   +7 more
doaj   +1 more source

Drug-Induced Fuchs Syndrome With Isolated Oral Involvement: A Rare Case Report. [PDF]

Case Rep Dermatol Med
Paudel S, Bhatt MK, Chaudhary SK, Silwal S, Parajuli A, Kafle PK.   +5 more
europepmc   +1 more source

A DEVICE FOR ANALYZING DRUG‐INDUCED RESPONSES IN FREELY MOVING MICE¹ [PDF]

, 1972
Ronald K. Siegel, M. A. Lee, Murray E. Jarvik   +2 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Previously Incarcerated Veteran: A Case of Drug-Induced Parkinsonism. [PDF]

Cureus
Bailey BR, Mason A, Dinh V.
europepmc   +1 more source

Drug-Induced Rhabdomyolysis Atlas (DIRA) for idiosyncratic adverse drug reaction management

, 2018
Zhining Wen, Liang Yu, Yingyi Hao, Brian Delavan, Ruili Huang, Mike Mikailov, Weida Tong, Menglong Li, Zhichao Liu   +8 more
openalex   +2 more sources