Results 11 to 20 of about 10,944,767 (389)
Drug-induced liver injury. [PDF]
Clinical medicine (London), 2016 Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the clinical setting is idiosyncratic in nature because affected individuals ...
D. Katarey, S. Verma
semanticscholar +2 more sources
Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias [PDF]
Toxicological Sciences, 2017 Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
K. Blinova +17 more
semanticscholar +3 more sources
Hepatology Communications, 2017 Cholestatic drug‐induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition. The clinical presentation of drug‐induced cholestasis includes bland cholestasis, cholestatic hepatitis, secondary sclerosing cholangitis,
Vinay Sundaram, Einar Bjornsson
openaire +5 more sources
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.
American Journal of Gastroenterology, 2021 Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver ...
M. F. Naga P. Chalasani +4 more
semanticscholar +1 more source
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
Frontiers in Cell and Developmental Biology, 2022 Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two.
Wen Gao +7 more
semanticscholar +1 more source
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
Science, 2021 Screening for drugs that don't work In the battle against COVID-19, drugs discovered in repurposing screens are of particular interest because these could be rapidly implemented as treatments. However, Tummino et al.
Tia A. Tummino +28 more
semanticscholar +1 more source
Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity
Cell Death and Disease, 2021 Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
X. Shen +4 more
semanticscholar +1 more source
Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association.
Circulation, 2020 Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological ...
J. Tisdale +6 more
semanticscholar +1 more source
Phenytoin-associated movement disorder: A literature review
Tzu Chi Medical Journal, 2022 Phenytoin (PHT) was first synthesized as a barbiturate derivative and was approved in 1953 by the Food and Drug Administration. This work aimed to review the pathophysiology, epidemiology, clinical presentation, and treatment of PHT-associated movement ...
Jamir Pitton Rissardo +1 more
doaj +1 more source
BMC Cancer, 2019 Background Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with discrepant conclusions reached.
Shan Tang +13 more
doaj +1 more source