Results 191 to 200 of about 1,693,725 (358)

Drug Induced Disease

International Journal of Clinical Practice, 1968
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma

JAAD Case Reports, 2020
Taylor Novice, BS, Ji Won Ahn, MD, Ryan Wilcox, MD, PHD, Trilokraj Tejasvi, MBBS, Alexandra Hristov, MD, Jennifer Mancuso, MD   +5 more
doaj   +1 more source

Is the combination of pentoxifylline and tocopherol really effective in the treatment of drug-induced osteonecrosis of the jaws? Literature review

, 2022
Samir Mainassara Chékaraou, Soukaina Essaket, Bassima Chami   +2 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Mechanotyping of Organoids for Assessing Drug-Induced Injuries. [PDF]

Adv Mater
Kaynak M, Aşık MD, Inan EE, Prondzynski M, Ghasemzadeh H, Poorghani A, Tharani Y, Holtz M, Mehta DD, Pu WT, Muratoglu OK, Yarmush ML, Alexeev A, Usta OB.   +13 more
europepmc   +1 more source

Ticagrelor-Induced Pneumonitis and Subsequent Pulmonary Hemorrhage; Drug Rash with Eosinophilia Due to Boceprevir; Hepatitis C Reactivation after Starting Infliximab; Hydralazine-Associated Immune Glomerulonephritis; Fluoroquinolones and Retinal Detachment

, 2014
Michael A. Mancano
openalex   +1 more source

Drug-induced hepatic cholestasis in the ICU: a case-control study [PDF]

, 2010
David Williamson, Marie-Eve Bédard Dufresne, Valérie Bonhomme, Martin Albert, Colin Verdant, AJ Frenette   +5 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source