Results 201 to 210 of about 10,944,767 (389)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Opisthotonus in Drug-Induced Dystonic Syndrome [PDF]

, 1964
F J Lichtigfeld
openalex   +1 more source

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Nature reviews. Drug discovery, 2019
Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick, I. Copple, Helga H. J. Gerets, Chris E. P. Goldring, A. Guillouzo, Philip Hewitt, M. Ingelman-Sundberg, Klaus Gjervig Jensen, Satu Juhila, U. Klingmüller, G. Labbe, M. Liguori, C. Lovatt, P. Morgan, D. Naisbitt, Raymond H. H. Pieters, J. Snoeys, B. van de Water, Dominic P. Williams, B. K. Park   +21 more
semanticscholar   +1 more source

Drug-induced oesophageal injury. [PDF]

, 1979
Fort Collins, H R Matthews, Sarah E. Baker, Jana Straková   +3 more
openalex   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Drug-induced neuropathies

Family Medicine & Primary Care Review, 2015
Marta Banach, Judyta K. Juranek, Jakub Antczak   +2 more
doaj   +1 more source

Drug Induced Psychosis [PDF]

British Journal of Psychiatry, 1996
Clare Brabbins, Robert J. Poole
openaire   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Adenosine 3',5'-cyclic monophosphate and morphology in Neurospora crassa: drug-induced alterations [PDF]

, 1975
William Scott, Bruce Solomon
openalex   +1 more source