Results 231 to 240 of about 6,563,401 (267)

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Linking the relationship between drug-induced osteoporosis and the gut microbiota. [PDF]

Front Endocrinol (Lausanne)
Martiniakova M, Sarocka A, Penzes N, Mondockova V, Sevcikova A, Ciernikova S, Kovacova V, Biro R, Folwarczna J, Omelka R.   +9 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Drug-induced metabolic remodeling promotes antimicrobial activity in macrophages and extends longevity in vivo. [PDF]

Life Sci Alliance
Hollmann C, Chan Park E, Liu Z, Nourollahi F, Bašēns EE, Dietz J, Waghmare TS, Vora M, Nikolayshvili G, Kane NS, Li T, Imdahl F, Macleod KF, Nora-Krukle Z, Elashiry MM, Rongo C, Prusty BK.   +16 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Drug-Induced Reduction in 80Q Aggregates in a <i>Dictyostelium discoideum</i> Model of PolyQ Disease. [PDF]

Biomedicines
Upadhyay B, Akhtar A, Rawat R, Jain M.
europepmc   +1 more source

Precision treatment and frontier advances of glycyrrhizin preparations in drug-induced liver injury (DILI). [PDF]

Front Pharmacol
Qiu D, Gao Z, Zhang L, Ma T, Wei X, Zhang Z, Cao W, Li X, Wang S, Deng W, Zhang Y, Yao L, Wang S, Jiang Y, Xie Y, Li M.   +15 more
europepmc   +1 more source

Fulminant drug-induced immune thrombocytopenia in polycystic kidney disease with cyst infection. [PDF]

CEN Case Rep
Iwamura N, Matsukuma Y, Iwamura K, Zhang Y, Yamada S, Nakamura K, Sakoda T, Kanaji S, Nakano T, Ago T.   +9 more
europepmc   +1 more source