Results 41 to 50 of about 10,944,767 (389)

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

Nature, 2017
Therapies that target signalling molecules that are mutated in cancers can often have substantial short-term effects, but the emergence of resistant cancer cells is a major barrier to full cures.
Sydney M. Shaffer, Margaret C. Dunagin, Stefan R. Torborg, E. Torre, Benjamin L. Emert, C. Krepler, M. Beqiri, Katrin Sproesser, Patricia Brafford, M. Xiao, Elliott R Eggan, Ioannis Anastopoulos, C. A. Vargas-Garcia, Abhyudai Singh, K. Nathanson, M. Herlyn, A. Raj   +16 more
semanticscholar   +1 more source

Drug-Induced Interstitial Lung Disease: A Systematic Review

Journal of Clinical Medicine, 2018
Background: Drug-induced interstitial lung disease (DIILD) occurs as a result of numerous agents, but the risk often only becomes apparent after the marketing authorisation of such agents.
S. Skeoch, N. Weatherley, A. Swift, A. Oldroyd, C. Johns, C. Hayton, A. Giollo, J. Wild, J. Waterton, M. Buch, K. Linton, I. Bruce, C. Leonard, S. Bianchi, N. Chaudhuri   +14 more
semanticscholar   +1 more source

Stochastic Ordering under Conditional Modelling of Extreme Values: Drug-Induced Liver Injury [PDF]

, 2014
Drug-induced liver injury (DILI) is a major public health issue and of serious concern for the pharmaceutical industry. Early detection of signs of a drug's potential for DILI is vital for pharmaceutical companies' evaluation of new drugs.
Box, Coles, Coles, Cox, Davison, Eastoe, Food and Drug Administration, Genest, Heffernan, Hilal, Jameson, Joe, Keef, Keef, Koenker, Ledford, Nelsen, Papastathopoulos, Paulo, Schmid, Sibuya, Southworth, Southworth, Tiago de Oliveira, Yu, Zimmerman, Zimmerman   +26 more
core   +1 more source

Drug-induced heart failure [PDF]

, 1999
Heart failure is a clinical syndrome that is predominantly caused by cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce heart failure in patients without concurrent cardiovascular ...
Feenstra, Johannes, Grobbee, Diederick E, Remme, Willem J, Stricker, Bruno H.Ch   +3 more
core   +1 more source

Drug-induced psoriasis

Indian Journal of Rheumatology, 2019
Psoriasis is known to be triggered by a number of factors including drugs. Some therapeutic agents for the treatment of psoriasis are also known to have a paradoxical effect and alter the course of the disease.
Sunil Dogra, Divya Kamat
doaj   +1 more source

Drug-induced metabolic acidosis [PDF]

, 2017
Summary: Drug causes of metabolic acidosis are numerous and their mechanisms are diverse. Broadly, they can cause metabolic acidosis with either a normal anion gap (e.g. drug-induced renal tubular acidosis) or an elevated anion gap (e.g.
Boton, Burdett, Burges, Dragovic, Fenves, Figge, Gerbaud, Hunter, Hussain, Kam, Karet, Knights, Kraut, Lee, Mirza, Oh, O’Connell, Peters, Porras, Reddi, Reyes, Robergs, Roscoe, Salpeter, Sawaya, Skinner, Soriano, Stewart, Tsao, Viollet, Walsh, Yombi, Yunos, Zamlauski-Tucker   +33 more
core   +1 more source

Emerging mechanisms of drug-induced phospholipidosis

Biological chemistry, 2019
Drug-induced phospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of phospholipids. Its cellular mechanism is still not well understood, but it is known that cationic amphiphilic drugs can induce it. These drugs have a
Bernadette Breiden, K. Sandhoff
semanticscholar   +1 more source

Buparvaquone Intoxication: Report of a Life-Threatening Thrombocytopenia in a Child and Review of Literature [PDF]

Journal of Clinical and Diagnostic Research, 2018
Drug induced thrombocytopenia is uncommon cause of life-threatening bleeding. The mechanisms may include bone marrow suppression or antibody-mediated platelet destruction. We report the case of a two-year-old boy with incedental ingestion of Buparvaquone
Omid Reza Zekavat, Gholamreza Fathpour, Mohammadreza Bordbar, Sezaneh Haghpanah, Nader Shakibazad   +4 more
doaj   +1 more source

Drug induced rhabdomyolysis

Current Opinion in Pharmacology, 2012
Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins. Given the fact that structurally not related compounds cause an identical phenotype pinpoints to common targets or pathways, responsible for executing rhabdomyolysis.
openaire   +2 more sources

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy

Nature Communications, 2018
Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of chemo-resistance in tumor cells. We observed that higher degree of phenotypic intra-tumor heterogeneity (ITH)
Ankur Sharma, Elaine Y. Cao, Vibhor Kumar, Vibhor Kumar, Xiaoqian Zhang, H. Leong, A. Wong, Neeraja Ramakrishnan, Muhammad Hakimullah, Hui Min Vivian Teo, F. Chong, Shumei Chia, M. Thangavelu, X. Kwang, Ruta Gupta, Jonathan R. Clark, G. Periyasamy, N. Iyer, R. Dasgupta   +18 more
semanticscholar   +1 more source