Results 81 to 90 of about 10,944,767 (389)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Drug-induced eosinophilic pneumonia

Medicine, 2018
Background and objective: Eosinophilic pneumonia (EP) is an important subset of patients who present with pulmonary infiltrates and eosinophilia (PIE). EP is classified by chronicity and etiology and drug-induced EP is the main cause of secondary EP. The
C. Bartal, I. Sagy, L. Barski
semanticscholar   +1 more source

Systemic similarity analysis of compatibility drug-induced multiple pathway patterns _in vivo_ [PDF]

, 2008
A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating the information exchanged between gene and the organ system
Weida Tong, Yi Wang, Yiyu Cheng, Yongyan Wang, Zhan-jun Zhang, Zhong Wang   +5 more
core   +1 more source

Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury [PDF]

, 2017
BACKGROUND & AIMS: Drug-induced liver injury (DILI) has features similar to those of other liver diseases including autoimmune hepatitis (AIH). We aimed to characterize the clinical and autoimmune features of liver injury caused by nitrofurantoin ...
Chalasani, Naga, de Boer, Ynto S., Drug-Induced Liver Injury Network., Hoofnagle, Jay H., Kleiner, David E., Kosinski, Andrzej S., Long, Nanye, Urban, Thomas J., Zhao, Zhen   +8 more
core   +2 more sources

Pancreatitis with use of new diabetic medications: a real-world data study using the post-marketing FDA adverse event reporting system (FAERS) database

Frontiers in Pharmacology
Background: Pancreatitis is characterized by inflammation of the pancreas and significantly affects quality of life. Less than 5% of pancreatitis cases are drug-induced, but recent evidence suggests a substantial risk associated with glucagon-like ...
Khalidah A. Alenzi, Khalidah A. Alenzi, Deemah Alsuhaibani, Bader Batarfi, Thamir M. Alshammari, Thamir M. Alshammari, Thamir M. Alshammari   +6 more
doaj   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Antithyroid drug-induced agranulocytosis [PDF]

, 1999
Thyrotoxicosis is a common endocrine disorder. Antithyroid drug therapy is the standard treatment for this disease, especially in young women of reproductive age. A serious side effect of antithyroid drug use, however, is agranulocytosis.
Lee, CH, Liang, RHS
core  

A Common Genetic Variant Risk Score is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. [PDF]

, 2017
Background -Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications.
Behr, ER, Blinova, K, Johannesen, L, Kosova, G, Mason, JW, Newton-Cheh, C, Roden, DM, Rosenberg, MA, Strauss, DG, Vicente, J, Weeke, P, Woosley, R   +11 more
core   +2 more sources

Etanercept – A culprit agent in acute pancreatitis?

Journal of Community Hospital Internal Medicine Perspectives, 2019
Drugs are responsible for 3%-5% of acute pancreatitis cases. There are a lot of medications that are known to cause acute pancreatitis, however only one case has been reported so far on Etanercept.
Ferry Gunawan, Beenish Fayyaz, Tania Octaria Mihardja   +2 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source