Results 11 to 20 of about 390,946 (318)
Menstrual cycle abnormalities in patients with prolactinoma and drug-induced hyperprolactinemia
Indian Journal of Endocrinology and Metabolism, 2017 Hyperprolactinemia affects the reproductive endocrine axis; however, the degree of dysfunction may vary depending on etiology. The aim of the present study was to analyze menstrual cyclicity in patients with prolactinoma and drug-induced hyperprolactinemia (DIH).Patients with prolactinoma and DIH were retrospectively analyzed for menstrual cyclicity at
Indu Chawla +6 more
doaj +6 more sources
Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism [PDF]
npj Parkinson's Disease, 2022 AbstractDrug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative parkinsonism, and bedside assessments are needed to differentiate between these conditions. We examined 34 U.S. Veterans with DIP using 123I-FP-CIT (DAT-SPECT) to identify underlying nigrostriatal degeneration. Participants were 94% male with mean age of 64.5 ±
Whitley W. Aamodt +6 more
doaj +4 more sources
Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue. [PDF]
Proceedings of the National Academy of Sciences, 1976 Various degrees of gingival overgrowth may occur in individuals taking diphenylhydantoin, a drug used widely in the treatment of epilepsy. The tissue overgrowth is made up predominantly of collagen, and may therefore be a useful model for analysis of fibrosis and some other connective tissue abnormalities.
Roy C. Page +3 more
+7 more sources
Japanese Journal of Medicine, 1991 Changes in plasma lipids and abnormal lipoproteins in a patient with ticlopidine hydrochloride-induced hepatitis were studied. Total cholesterol, free cholesterol and phospholipids increased markedly during cholestasis. Lipoprotein electrophoresis showed a large lipoprotein-X band and a relatively small alpha-lipoprotein band.
Yasuo Imai +4 more
openaire +5 more sources
Drug-induced Physeal Abnormalities in Preclinical Toxicity Studies [PDF]
Toxicologic Pathology, 2017 Most toxic physeal changes are characterized microscopically by altered chondrocyte development, proliferation, or maturation in the growth plate and eventually result in disordered appositional bone growth. Many therapeutic drugs directly or indirectly target proteins involved in chondrocytic differentiation and maturation pathways, so toxic physeal ...
Kendall S. Frazier
openaire +4 more sources
Protein trafficking abnormalities: a new mechanism in drug‐induced long QT syndrome [PDF]
British Journal of Pharmacology, 2005 Drug induced long QT syndrome (LQTS) can lead to cardiac arrhythmias and sudden death, and has emerged as a worldwide problem. Most drugs that cause this are thought to directly block a specific cardiac ion channel (KCNH2 or hERG) that carries the rapidly activating delayed rectifier potassium current, IKr.
Sridharan Rajamani +2 more
openaire +4 more sources
Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias [PDF]
Current Cardiology Reviews, 2016 Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced inhibition of K+ currents, IKs, IKr, IK1, and/or Ito, delay repolarization, prolong QT, and increase the risk of TdP.
Luigi X. Cubeddu
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Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome [PDF]
Biophysical Reviews, 2022 AbstractDrug-induced long QT syndrome (diLQTS) is the phenomenon by which the administration of drugs causes prolongation of cardiac repolarisation and leads to an increased risk of the ventricular tachycardia known as torsades de pointes (TdP). In most cases of diLQTS, the primary molecular target is the human ether-à-go-go-related gene protein (hERG)
Clifford TeBay +2 more
openaire +3 more sources
Drug-Induced Parkinsonism and Abnormal Involuntary Movements [PDF]
, 2012 Motor side effects emerging from the use of neuroleptics have been recognised since their first use in the 1950s. There is however an increasing awareness that other drug classes (in particular other psychotropic drugs and calcium channel blockers) are also implicated in the genesis of parkinsonism and other abnormal involuntary movements.
Craig Ritchie
openaire +3 more sources
A History of Drug‐Induced Torsades de Pointes Is Associated With T‐wave Morphological Abnormalities [PDF]
Clinical Pharmacology & Therapeutics, 2017 The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T‐wave morphology compared to Fridericia‐corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (–TdP).
Bhuiyan T.A. +6 more
openaire +7 more sources