Results 31 to 40 of about 5,793,514 (248)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system. [PDF]

, 2013
BACKGROUND: Drug-related adverse events remain an important cause of morbidity and mortality and impose huge burden on healthcare costs. Routinely collected electronic healthcare data give a good snapshot of how drugs are being used in 'real-world ...
van der Lei Johan, Sturkenboom, Miriam, EU-ADR consortium, Lars Pedersen (65617), Lorenza Scotti, Paul Avillach (173608), Furlong L, Sturkenboom, M., Helgee Ernst Ahlberg, Avillach, P, Gini R, Scott Boyer (173647), Avillach, P. (Paul), Pedersen, L. (Lars), Miriam Sturkenboom (408749), Mazzaglia, G, Mestres J, Mestres, Jordi, Bauer Mehren, A, Scotti, L, Picelli, G. (Gino), Ernst Ahlberg Helgee (173638), José Luis Oliveira (451346), Prieto-Merino D, Scotti, Lorenza, Coloma PM, Furlong, L.I. (Laura), Mazzaglia Giampiero, Gino Picelli (451351), Matthews, J, Herings, Ron, Giampiero Mazzaglia, Johan van der Lei, Matthews J, Matthews, J.N. (Justin Neil), Mestres i López, Jordi, Kors, J, Sanz, F, David Prieto-Merino (294768), van Mulligen, Erik, Prieto-Merino David, Molokhia M, Picelli G, Mazzaglia, Giampiero, Schuemie, Martijn J, Miriam Sturkenboom, Gini Rosa, Schuemie, Martijn J., Scotti L, van Mulligen, E, van Mulligen E, Prieto-Merino, David, Gianluca Trifirò, Sanz Ferran, Molokhia Mariam, Molokhia, Mariam, Gini, R, Martijn J. Schuemie (257191), Sturkenboom, M.C.J.M. (Miriam), Sanz F, Helgee, E.A. (Ernst Ahlberg), Helgee, EA, Martijn J Schuemie, Rosa Gini (451348), Molokhia, M. (Mariam), Schuemie MJ, Prieto-Merino, D. (David), Coloma Preciosa M., Molokhia, M, Johan van der Lei (451352), Justin Matthews, Mestres Jordi, Jordi Mestres (168498), Scotti Lorenza, Anna Bauer-Mehren, van der Lei, Johan, Schuemie, Martijn, Mazzaglia, G. (Giampiero), Paul Avillach, Erik van Mulligen, Oliveira JL, Sturkenboom, MCJM, Lorenza Scotti (365932), Jordi Mestres, Furlong Laura, Erik van Mulligen (451345), Helgee EA, Herings, R.M.C. (Ron), Trifirò, Gianluca, Laura Furlong, Boyer, S, Picelli, Gino, Coloma, Preciosa M., Avillach Paul, Schuemie Martijn J., Mazzaglia G, Lars Pedersen, Ferran Sanz (89706), Bauer-Mehren Anna, David Prieto-Merino, van der Lei, J, Boyer, Scott, Furlong, Laura I., 1971-, Preciosa M. Coloma (451342), Matthews Justin, Prieto Merino, D, Coloma, P.M. (Preciosa), Ferran Sanz, Sturkenboom M, Kors, Jan; id_orcid, Oliveira, J, Picelli, G, Mulligen, E.M. (Erik) van, Jan Kors, Kors Jan, Lei, J. (Johan) van der, Trifirò G, Herings, R, Prieto-Merino, D, Justin Matthews (451347), Kors, Jan, Lei, Johan, Trifirò, G. (Gianluca), ?, ?, Gini, R. (Rosa), Rosa Gini, van der Lei J, Coloma, Preciosa M, Bauer-Mehren, A. (Anna), Jan Kors (390655), Picelli Gino, Scott Boyer, Avillach, Paul, Coloma, Preciosa, Gini, Rosa, Mariam Molokhia, Martijn J. Schuemie, Oliveira, JL, Ernst Ahlberg Helgee, Helgee, Ernst Ahlberg, Gino Picelli, Sturkenboom Miriam, Oliveira, José Luis, Bauer-Mehren, A, Bauer-Mehren A, Ron Herings (451349), Pedersen, L, Boyer S, Mestres, J, Pedersen, Lars, van Mulligen Erik, Oliveira José Luis, Coloma, P, Mestres, J. (Jordi), Pedersen Lars, Boyer, S. (Scott), Matthews, Justin, Herings Ron, Kors J, Mariam Molokhia (54874), Schuemie, M.J. (Martijn), Sanz, Ferran, Kors, J.A. (Jan), Anna Bauer-Mehren (173597), Pedersen L, Boyer Scott, Trifirò, G, Preciosa M Coloma, Scotti, L. (Lorenza), José Luis Oliveira, Helgee, E, Ron Herings, Gianluca Trifirò (451343), Sanz, F. (Ferran), Furlong, L, Oliveira, J.L. (José Luis), Preciosa M. Coloma, Schuemie, M, Laura Furlong (451344), Avillach P, Furlong, Laura, Bauer-Mehren, Anna, Giampiero Mazzaglia (451350), Trifirò Gianluca, Herings R, TRIFIRO', Gianluca, EU ADR consortium, van Mulligen, Erik; id_orcid, Bauer Mehren A, Prieto Merino D   +189 more
core   +1 more source

Atrial Fibrillation Associated with Anticancer Drugs

Безопасность и риск фармакотерапии, 2020
Atrial fibrillation is a serious adverse reaction associated with the use of anticancer drugs. The aim of the study was to analyse scientific literature on the prevalence, pathophysiological mechanisms, and risk factors of anticancer drug-induced atrial ...
O. D. Ostroumova, M. S. Chernyaeva, A. I. Kochetkov, D. I. Bakhteeva, S. N. Ivanov, D. A. Sychev   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Lamotrigine hypersensitivity syndrome and spiking fever

Indian Journal of Dermatology, 2012
We report a case of a 26 year old woman with rash, lymphadenopathy, liver enzyme abnormalities and spiking fever. She was diagnosed with drug-induced hypersensitivity syndrome (DHS) to lamotrigine.
Christiaan V Bakker, Vincent Noordhoek Hegt, Marinus C G Van Praag   +2 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Trends in overdose and other drug-induced deaths in Australia, 2004-2023 [PDF]

The National Illicit Drug Indicators Project provides epidemiological data on trends over time in drug-related harms and forms part of the broader Drug Trends program.
Chrzanowska, Agata ; https://orcid.org/, Degenhardt, Louisa, Sutherland, Rachel ; https://orcid.org/, Man, Nicola, Peacock, Amy   +4 more
core   +1 more source

Obstrução intestinal após uso de infliximab no tratamento de fístula êntero-cutânea na doença de Crohn

Revista do Colégio Brasileiro de Cirurgiões
Crohn's disease is often complicated by the development of fistulas. Infliximab, a monoclonal antibody that binds tumor necrosis factor a have shown to be successful in the treatment of fistulizing Crohn's disease.
Carolina Gomes Gonçalves, Júlio Cezar Uili Coelho, Heda Maria Braska dos Santos Amarante   +2 more
doaj   +1 more source

Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings.

PLoS ONE, 2016
BackgroundConcerning the risk of antidepressant induced liver injury, it is not clear whether psychiatrists perform a liver function test (LFT) and whether an increase in aminotransferase levels should contraindicate antidepressant treatment.AimTo ...
Cosmin Sebastian Voican, Severine Martin, Céline Verstuyft, Emmanuelle Corruble, Gabriel Perlemuter, Romain Colle   +5 more
doaj   +1 more source

Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To explore the genotoxic potential and histopathological changes induced in liver, kidney, testis, brain and heart after using the antibiotic drug amoxicillin/clavulanic acid (4:1).
Maha A. Fahmy, Ayman A. Farghaly, Enayat A. Omara, Zeinab M. Hassan, Fawzia A.E. Aly, Souria M. Donya, Aziza A.E. Ibrahim, Elsayed M. Bayoumy   +7 more
doaj   +1 more source