Results 1 to 10 of about 450,317 (308)

Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras

Biomolecules, 2020
Zebrafish is an elegant vertebrate employed to model the pathological etiologies of human maladies such as cardiac diseases. Persistent physiological stresses can induce abnormalities in heart functions such as cardiac hypertrophy (CH), which can lead to
Acharya Balkrishna, Yashika Rustagi, Kunal Bhattacharya, Anurag Varshney   +3 more
doaj   +1 more source

Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias [PDF]

Current Cardiology Reviews, 2016
Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced inhibition of K+ currents, IKs, IKr, IK1, and/or Ito, delay repolarization, prolong QT, and increase the risk of TdP.
openaire   +2 more sources

Examining the reversibility of long-term behavioral disruptions in progeny of maternal SSRI exposure [PDF]

, 2018
Serotonergic dysregulation is implicated in numerous psychiatric disorders. Serotonin plays widespread trophic roles during neurodevelopment; thus perturbations to this system during development may increase risk for neurodevelopmental disorders ...
Akula, Shyam, Chandler, Krystal, Corbett, Adrian M, Dougherty, Joseph D, Maloney, Susan E, McCullough, Katherine B, McGowin, Audrey E, Rieger, Michael A   +7 more
core   +1 more source

Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals [PDF]

, 2016
Chemo immunotherapies for chronic lymphocytic leukemia (CLL) showed a positive impact on clinical outcome, but many patients relapsed or become refractory to the available treatments.
Facco, Monica, Frezzato, Federica, Martini, Veronica, Semenzato, Gianpietro, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea   +7 more
core   +1 more source

Consumo de medicamentos, álcool e fumo na gestação e avaliação dos riscos teratogênicos

Revista Gaúcha de Enfermagem
Medicações, álcool e fumo podem gerar danos fetais. Este estudo transversal foi realizado entre 2006 e 2007, com 326 puérperas do Hospital Geral de Fortaleza, para avaliar o uso de medicamentos, álcool e fumo na gestação e potencial teratogênico ...
Rebeca Silveira Rocha, Samara Cavalcante Bezerra, José Welington de Oliveira Lima, Fabrício da Silva Costa   +3 more
doaj  

Diphenylhydantoin (phenytoin)-induced chronic pulmonary disease

Lung India, 2009
Drug-induced respiratory diseases are difficult to diagnose and therefore usually not identified, probably underestimated and under-reported. We report a case of diphenylhydantoin/phenytoin-induced chronic pulmonary disease in a 62-year-old male patient ...
Dixit Ramakant, Dixit Kalpana, Nuwal Paras, Banerjee Arunima, Sharma Sidharth, Dave Lokendra   +5 more
doaj  

Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues [PDF]

, 2011
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress.
Doctrow, Susan R., Fish, Brian, Hill, Richard P., Huffman, Karl D., Lazarova, Zelmira, Mahmood, Javed, Medhora, Meetha, Molthen, Robert C., Moulder, John E., Rosenthal, Rosalind A., Sonis, Stephen T., Tofilon, Philip J.   +11 more
core   +2 more sources

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro [PDF]

, 2013
Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue.
Chen, Rongchang, Dong, Xi, Luo, Yun, Qin, Meng, Sun, Guibo, Sun, Hong, Sun, Xiaobo, Wang, Min, Wu, Ping, Yao, Fan, Zhang, Qiang   +10 more
core   +3 more sources

p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia [PDF]

, 2011
Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment ...
Anjali Advani, Edward Copelan, James C. Mulloy, PhD, Jaroslaw Maciejewski, Kevin Link, Kwok-Peng Ng, Matt Kalaycio, Mikkael Sekeres, Quteba Ebrahem, Reda Mahfouz, Ronald Sobecks, Soledad Negrotto, Tomas Radivoyevitch, Xiaorong Gu, Yogen Saunthararajah, Zhenbo Hu   +15 more
core   +2 more sources

Plasmapheresis in thyrotoxicosis: a single-center case series

Journal of Medical Case Reports
Background Plasmapheresis represent an alternative therapeutic option for hyperthyroidism with thyroid storm or refractory cases. It provides a rapid decrease in plasma thyroid hormones and anti-thyroid antibodies. The aim of this paper was to report our
I. Rami, D. Zerrouki, I. Assarrar, S. Rouf, H. Latrech   +4 more
doaj   +1 more source