Results 31 to 40 of about 266,501 (163)

Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To explore the genotoxic potential and histopathological changes induced in liver, kidney, testis, brain and heart after using the antibiotic drug amoxicillin/clavulanic acid (4:1).
Maha A. Fahmy, Ayman A. Farghaly, Enayat A. Omara, Zeinab M. Hassan, Fawzia A.E. Aly, Souria M. Donya, Aziza A.E. Ibrahim, Elsayed M. Bayoumy   +7 more
doaj   +1 more source

Protein trafficking abnormalities: a new mechanism in drug‐induced long QT syndrome [PDF]

British Journal of Pharmacology, 2005
Drug induced long QT syndrome (LQTS) can lead to cardiac arrhythmias and sudden death, and has emerged as a worldwide problem. Most drugs that cause this are thought to directly block a specific cardiac ion channel (KCNH2 or hERG) that carries the rapidly activating delayed rectifier potassium current, IKr.
Lee L, Eckhardt, Sridharan, Rajamani, Craig T, January   +2 more
openaire   +2 more sources

Insuficiencia renal aguda secundaria a aciclovir: Reporte de caso y revisión de la literatura

Infectio
La excreción renal es uno de los principales mecanismos para la eliminación de medicamentos, lo cual convierte a los riñones en blanco frecuente de lesión. Distintos medicamentos han sido asociados a desarrollo de insuficiencia renal aguda.
Jorge E. Machado-Alba, Diego Alejandro Medina-Morales, Ilsa Yadira Parrado-Fajardo   +2 more
doaj   +1 more source

Toxicology knowledge graph for structural birth defects

Communications Medicine, 2023
Background Birth defects are functional and structural abnormalities that impact about 1 in 33 births in the United States. They have been attributed to genetic and other factors such as drugs, cosmetics, food, and environmental pollutants during ...
John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Giacomo B. Marino, Vivian Utti, Sherry L. Jenkins, Taha Mohseni Ahooyi, Cristian G. Bologa, Jeremy J. Yang, Jessica L. Binder, Praveen Kumar, Christophe G. Lambert, Jeffrey S. Grethe, Eric Wenger, Deanne Taylor, Tudor I. Oprea, Bernard de Bono, Avi Ma’ayan   +17 more
doaj   +1 more source

The Teratogenic Effects of Acetaminophen on the Mice Embryo

پزشکی بالینی ابن سینا, 2000
Acetaminophen is a  widely used  analegesis and antipyretic which is    considered  safe  at  therapeutic  levels . This  medicine is  also  a  kind  of    influensive substiution via the gut, it is metabolized in liver and  converted    to consistant 
Mahdi Jalali, Kazem Parivar, Mohammadreza Nikravesh, Mohammadreza Hossieni-Ravesh   +3 more
doaj  

A History of Drug‐Induced Torsades de Pointes Is Associated With T‐wave Morphological Abnormalities [PDF]

Clinical Pharmacology & Therapeutics, 2017
The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T‐wave morphology compared to Fridericia‐corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (–TdP).
Bhuiyan T.A., Graff C., Kanters J.K., Melgaard J., Toft E., K??b S., Struijk J.J.   +6 more
openaire   +5 more sources

Sperm abnormality toxicity due to cyclosporine A and the ameliorative effect of royal jelly in male rats

Journal of Basic and Applied Zoology, 2016
The immunosuppressive drug, utilized widely in Egypt, cyclosporine A was studied to evaluate its toxicity in male rats. Animals were divided into a control (untreated), 3 groups treated intraperitoneally with 20, 40 and 60 m/kg cyclosporine A for 5, 10 ...
Azza M. Gawish, Samya ElFiky, Mary Therase, Amira AbdElraaof, Wagdi Khalil, Karima A. Mohamed   +5 more
doaj   +1 more source

Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias [PDF]

Current Cardiology Reviews, 2016
Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced inhibition of K+ currents, IKs, IKr, IK1, and/or Ito, delay repolarization, prolong QT, and increase the risk of TdP.
openaire   +2 more sources

Drug-Induced Hematologic Syndromes

Advances in Hematology, 2009
Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system.
David M. Mintzer, Shira N. Billet, Lauren Chmielewski   +2 more
doaj   +1 more source

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Frontiers in Physiology, 2017
Background: Cellular repolarization abnormalities occur unpredictably due to disease and drug effects, and can occur even in cardiomyocytes that exhibit normal action potentials (AP) under control conditions.
Oliver J. Britton, Alfonso Bueno-Orovio, László Virág, András Varró, Blanca Rodriguez   +4 more
doaj   +1 more source