Results 51 to 60 of about 5,793,227 (293)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Trends in overdose and other drug-induced deaths in Australia, 2004-2023 [PDF]
The National Illicit Drug Indicators Project provides epidemiological data on trends over time in drug-related harms and forms part of the broader Drug Trends program.
Chrzanowska, Agata ; https://orcid.org/ +4 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Methods for Trends in overdose and other drug-induced deaths in Australia, 2004-2023 [PDF]
The National Illicit Drug Indicators Project provides epidemiological data on trends over time in drug-related harms and forms part of the broader Drug Trends program.
Chrzanowska, Agata ; https://orcid.org/ +4 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Lamotrigine hypersensitivity syndrome and spiking fever
Indian Journal of Dermatology, 2012 We report a case of a 26 year old woman with rash, lymphadenopathy, liver enzyme abnormalities and spiking fever. She was diagnosed with drug-induced hypersensitivity syndrome (DHS) to lamotrigine.
Christiaan V Bakker +2 more
doaj +1 more source
Protein trafficking abnormalities: a new mechanism in drug‐induced long QT syndrome [PDF]
British Journal of Pharmacology, 2005 Drug induced long QT syndrome (LQTS) can lead to cardiac arrhythmias and sudden death, and has emerged as a worldwide problem. Most drugs that cause this are thought to directly block a specific cardiac ion channel (KCNH2 or hERG) that carries the rapidly activating delayed rectifier potassium current, IKr.
Lee L, Eckhardt +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Revista do Colégio Brasileiro de CirurgiõesCrohn's disease is often complicated by the development of fistulas. Infliximab, a monoclonal antibody that binds tumor necrosis factor a have shown to be successful in the treatment of fistulizing Crohn's disease.
Carolina Gomes Gonçalves +2 more
doaj +1 more source
PLoS ONE, 2016 BackgroundConcerning the risk of antidepressant induced liver injury, it is not clear whether psychiatrists perform a liver function test (LFT) and whether an increase in aminotransferase levels should contraindicate antidepressant treatment.AimTo ...
Cosmin Sebastian Voican +5 more
doaj +1 more source