Results 51 to 60 of about 293,712 (302)
, 2021 Drug-induced hyperglycemia is a clinically relevant condition which is often underestimated. At the same time, it is frequent because many of the widely used drugs may cause it.
Valcheva-Kuzmanova, Stefka; Medical University of Varna +2 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Characteristics of Idiosyncratic Drug-induced Liver Injury in Children
, 2011 Background: The spectrum and severity of idiosyncratic drug-induced liver injury (DILI) in children are not well established. Patients and methods: The DILIN (Drug-Induced Liver Injury Network) Prospective Study is a longitudinal multicenter study ...
Gu, Jiezhun +12 more
core +1 more source
, 2021 Parkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral ...
Barcia Hernández, Emilia María +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Revista do Colégio Brasileiro de CirurgiõesCrohn's disease is often complicated by the development of fistulas. Infliximab, a monoclonal antibody that binds tumor necrosis factor a have shown to be successful in the treatment of fistulizing Crohn's disease.
Carolina Gomes Gonçalves +2 more
doaj +1 more source
Lamotrigine hypersensitivity syndrome and spiking fever
Indian Journal of Dermatology, 2012 We report a case of a 26 year old woman with rash, lymphadenopathy, liver enzyme abnormalities and spiking fever. She was diagnosed with drug-induced hypersensitivity syndrome (DHS) to lamotrigine.
Christiaan V Bakker +2 more
doaj +1 more source
Toxicology knowledge graph for structural birth defects
Communications Medicine, 2023 Background Birth defects are functional and structural abnormalities that impact about 1 in 33 births in the United States. They have been attributed to genetic and other factors such as drugs, cosmetics, food, and environmental pollutants during ...
John Erol Evangelista +17 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source