Results 61 to 70 of about 450,317 (308)

Obstrução intestinal após uso de infliximab no tratamento de fístula êntero-cutânea na doença de Crohn

Revista do Colégio Brasileiro de Cirurgiões
Crohn's disease is often complicated by the development of fistulas. Infliximab, a monoclonal antibody that binds tumor necrosis factor a have shown to be successful in the treatment of fistulizing Crohn's disease.
Carolina Gomes Gonçalves, Júlio Cezar Uili Coelho, Heda Maria Braska dos Santos Amarante   +2 more
doaj   +1 more source

Lamotrigine hypersensitivity syndrome and spiking fever

Indian Journal of Dermatology, 2012
We report a case of a 26 year old woman with rash, lymphadenopathy, liver enzyme abnormalities and spiking fever. She was diagnosed with drug-induced hypersensitivity syndrome (DHS) to lamotrigine.
Christiaan V Bakker, Vincent Noordhoek Hegt, Marinus C G Van Praag   +2 more
doaj   +1 more source

Toxicology knowledge graph for structural birth defects

Communications Medicine, 2023
Background Birth defects are functional and structural abnormalities that impact about 1 in 33 births in the United States. They have been attributed to genetic and other factors such as drugs, cosmetics, food, and environmental pollutants during ...
John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Giacomo B. Marino, Vivian Utti, Sherry L. Jenkins, Taha Mohseni Ahooyi, Cristian G. Bologa, Jeremy J. Yang, Jessica L. Binder, Praveen Kumar, Christophe G. Lambert, Jeffrey S. Grethe, Eric Wenger, Deanne Taylor, Tudor I. Oprea, Bernard de Bono, Avi Ma’ayan   +17 more
doaj   +1 more source

Methotrexate hepatotoxicity in patients with rheumatoid arthritis. [PDF]

, 2010
BACKGROUND Increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (MTX). The aim of this study, therefore was to evaluate the incidence of MTX induced hepatotoxicity and its risk ...
Akhlaghi, M, Anvari, B, Kolahdoozan, S, Shahraeeni, S, Sotoudehmanesh, R   +4 more
core  

Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]

, 1990
Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H., Jochum, Marianne, Schiffl, H., Spannagl, Michael   +3 more
core   +1 more source

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

Protein trafficking abnormalities: a new mechanism in drug‐induced long QT syndrome [PDF]

British Journal of Pharmacology, 2005
Drug induced long QT syndrome (LQTS) can lead to cardiac arrhythmias and sudden death, and has emerged as a worldwide problem. Most drugs that cause this are thought to directly block a specific cardiac ion channel (KCNH2 or hERG) that carries the rapidly activating delayed rectifier potassium current, IKr.
Lee L, Eckhardt, Sridharan, Rajamani, Craig T, January   +2 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings.

PLoS ONE, 2016
BackgroundConcerning the risk of antidepressant induced liver injury, it is not clear whether psychiatrists perform a liver function test (LFT) and whether an increase in aminotransferase levels should contraindicate antidepressant treatment.AimTo ...
Cosmin Sebastian Voican, Severine Martin, Céline Verstuyft, Emmanuelle Corruble, Gabriel Perlemuter, Romain Colle   +5 more
doaj   +1 more source

Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To explore the genotoxic potential and histopathological changes induced in liver, kidney, testis, brain and heart after using the antibiotic drug amoxicillin/clavulanic acid (4:1).
Maha A. Fahmy, Ayman A. Farghaly, Enayat A. Omara, Zeinab M. Hassan, Fawzia A.E. Aly, Souria M. Donya, Aziza A.E. Ibrahim, Elsayed M. Bayoumy   +7 more
doaj   +1 more source