Results 41 to 50 of about 5,793,227 (293)

Diagnosis of drug induced liver injury using a lymphocyte blast transformation test based on whole blood culture [PDF]

, 1977
Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture ...
Takata, Shinji
core   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Indigenous Herbal Drug (Tinospora Cordifolia) Induced Liver Injury: A Case Report [PDF]

Bengal Physician Journal
Drug-induced liver injury (DILI) is a condition characterized by acute or chronic liver damage following the use of hepatotoxic drugs. It can be classified based on clinical presentation (hepatocellular, cholestasis, or mixed), mechanism of ...
Sounak Kumar Roy, Muniruddin SK, Subham Mondal, Sandipan Mukherjee, Santa Subhra Chatterjee   +4 more
doaj   +1 more source

Giant right coronary artery aneurysm. Case Report

Case Reports, 2020
Introduction: Coronary aneurysms are rare and are linked to drug abuse; symptomatology depends on the coronary anatomy. This is a case of acute coronary syndrome associated with a giant right coronary aneurysm.
Benjamín Iván Hernández-Mejía, Edison Ricardo Espinoza-Saquicela   +1 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system. [PDF]

, 2013
BACKGROUND: Drug-related adverse events remain an important cause of morbidity and mortality and impose huge burden on healthcare costs. Routinely collected electronic healthcare data give a good snapshot of how drugs are being used in 'real-world ...
van der Lei Johan, Sturkenboom, Miriam, EU-ADR consortium, Lars Pedersen (65617), Lorenza Scotti, Paul Avillach (173608), Furlong L, Sturkenboom, M., Helgee Ernst Ahlberg, Avillach, P, Gini R, Scott Boyer (173647), Avillach, P. (Paul), Pedersen, L. (Lars), Miriam Sturkenboom (408749), Mazzaglia, G, Mestres J, Mestres, Jordi, Bauer Mehren, A, Scotti, L, Picelli, G. (Gino), Ernst Ahlberg Helgee (173638), José Luis Oliveira (451346), Prieto-Merino D, Scotti, Lorenza, Coloma PM, Furlong, L.I. (Laura), Mazzaglia Giampiero, Gino Picelli (451351), Matthews, J, Herings, Ron, Giampiero Mazzaglia, Johan van der Lei, Matthews J, Matthews, J.N. (Justin Neil), Mestres i López, Jordi, Kors, J, Sanz, F, David Prieto-Merino (294768), van Mulligen, Erik, Prieto-Merino David, Molokhia M, Picelli G, Mazzaglia, Giampiero, Schuemie, Martijn J, Miriam Sturkenboom, Gini Rosa, Schuemie, Martijn J., Scotti L, van Mulligen, E, van Mulligen E, Prieto-Merino, David, Gianluca Trifirò, Sanz Ferran, Molokhia Mariam, Molokhia, Mariam, Gini, R, Martijn J. Schuemie (257191), Sturkenboom, M.C.J.M. (Miriam), Sanz F, Helgee, E.A. (Ernst Ahlberg), Helgee, EA, Martijn J Schuemie, Rosa Gini (451348), Molokhia, M. (Mariam), Schuemie MJ, Prieto-Merino, D. (David), Coloma Preciosa M., Molokhia, M, Johan van der Lei (451352), Justin Matthews, Mestres Jordi, Jordi Mestres (168498), Scotti Lorenza, Anna Bauer-Mehren, van der Lei, Johan, Schuemie, Martijn, Mazzaglia, G. (Giampiero), Paul Avillach, Erik van Mulligen, Oliveira JL, Sturkenboom, MCJM, Lorenza Scotti (365932), Jordi Mestres, Furlong Laura, Erik van Mulligen (451345), Helgee EA, Herings, R.M.C. (Ron), Trifirò, Gianluca, Laura Furlong, Boyer, S, Picelli, Gino, Coloma, Preciosa M., Avillach Paul, Schuemie Martijn J., Mazzaglia G, Lars Pedersen, Ferran Sanz (89706), Bauer-Mehren Anna, David Prieto-Merino, van der Lei, J, Boyer, Scott, Furlong, Laura I., 1971-, Preciosa M. Coloma (451342), Matthews Justin, Prieto Merino, D, Coloma, P.M. (Preciosa), Ferran Sanz, Sturkenboom M, Kors, Jan; id_orcid, Oliveira, J, Picelli, G, Mulligen, E.M. (Erik) van, Jan Kors, Kors Jan, Lei, J. (Johan) van der, Trifirò G, Herings, R, Prieto-Merino, D, Justin Matthews (451347), Kors, Jan, Lei, Johan, Trifirò, G. (Gianluca), ?, ?, Gini, R. (Rosa), Rosa Gini, van der Lei J, Coloma, Preciosa M, Bauer-Mehren, A. (Anna), Jan Kors (390655), Picelli Gino, Scott Boyer, Avillach, Paul, Coloma, Preciosa, Gini, Rosa, Mariam Molokhia, Martijn J. Schuemie, Oliveira, JL, Ernst Ahlberg Helgee, Helgee, Ernst Ahlberg, Gino Picelli, Sturkenboom Miriam, Oliveira, José Luis, Bauer-Mehren, A, Bauer-Mehren A, Ron Herings (451349), Pedersen, L, Boyer S, Mestres, J, Pedersen, Lars, van Mulligen Erik, Oliveira José Luis, Coloma, P, Mestres, J. (Jordi), Pedersen Lars, Boyer, S. (Scott), Matthews, Justin, Herings Ron, Kors J, Mariam Molokhia (54874), Schuemie, M.J. (Martijn), Sanz, Ferran, Kors, J.A. (Jan), Anna Bauer-Mehren (173597), Pedersen L, Boyer Scott, Trifirò, G, Preciosa M Coloma, Scotti, L. (Lorenza), José Luis Oliveira, Helgee, E, Ron Herings, Gianluca Trifirò (451343), Sanz, F. (Ferran), Furlong, L, Oliveira, J.L. (José Luis), Preciosa M. Coloma, Schuemie, M, Laura Furlong (451344), Avillach P, Furlong, Laura, Bauer-Mehren, Anna, Giampiero Mazzaglia (451350), Trifirò Gianluca, Herings R, TRIFIRO', Gianluca, EU ADR consortium, van Mulligen, Erik; id_orcid, Bauer Mehren A, Prieto Merino D   +189 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The side effects (cytogenetics ) of Methotrexate drug on male germ cells of Mus musculus

مجلة مركز بحوث التقنيات الاحيائية, 2011
In this study three doses (0.01, 0.02, 0.04) mgkg B.W of methotrexate drug which used, in the treatment of bladder cancer, were investigate in male germ cells of Mus musculus.
Abbas A. Mohammed, Ali A. Al-Temimi, Ahmed Abdul Amier Hussain Al-Amiery   +2 more
doaj   +1 more source

Atrial Fibrillation Associated with Anticancer Drugs

Безопасность и риск фармакотерапии, 2020
Atrial fibrillation is a serious adverse reaction associated with the use of anticancer drugs. The aim of the study was to analyse scientific literature on the prevalence, pathophysiological mechanisms, and risk factors of anticancer drug-induced atrial ...
O. D. Ostroumova, M. S. Chernyaeva, A. I. Kochetkov, D. I. Bakhteeva, S. N. Ivanov, D. A. Sychev   +5 more
doaj   +1 more source