Results 271 to 280 of about 1,381,560 (302)
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Drug-Like Property Concepts in Pharmaceutical Design
Current Pharmaceutical Design, 2009The pharmaceutical industry is facing an ever increasing challenge to deliver safer and more effective medicines. Traditionally, drug discovery programs were driven solely by potency, regardless of the properties. As a result, the development of non-drug-like molecules was costly, had high risk and low success rate.
Li, Di, Edward H, Kerns, Guy T, Carter
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Skin Occlusion: Treatment or Drug-Like Device?
Skin Pharmacology, 2009The effects of occlusion on skin function are described and reviewed. Occlusion seems to be not only a device applied on the skin surface, but, under certain conditions, a powerful treatment capable of inducing several changes on epidermal metabolism, skin flora, sweat glands and epidermal morphology.
E, Berardesca, H I, Maibach
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Lipid‐Bilayer Permeation of Drug‐Like Compounds
Chemistry & Biodiversity, 2009AbstractLipid‐bilayer permeation is determinant for the disposition of xenobiotics in the body. It controls the pharmacokinetic behavior of drugs and is, in many cases, a prerequisite for intracellular targeting. Permeation ofin vivobarriers is in general predicted from lipophilicity and related parameters.
Stefanie D, Krämer +4 more
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ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jun Xu, James Stevenson
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jun Xu, James Stevenson
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STEROIDAL THIOSEMICARBAZONES: DRUG-LIKENESS AND ANTIOXIDANT PROPERTIES
XXX Savetovanje o biotehnologiji sa međunarodnim učešćemThiosemicarbazones (TSCs) are well known for their diverse biological activities and wide-ranging applications. This study assessed the drug- likeness and antioxidant potential of previously synthesized steroidal TSCs with promising cytotoxicity. While all tested androstane TSCs are drug-like, they have poor water solubility, strong plasma protein ...
Živković, Marijana +4 more
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Two antiretroviral drugs likely to be confused
American Journal of Health-System Pharmacy, 1998J T, Johnson, E B, Dunn, J J, Wolfe
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Polish journal of pharmacology, 1999
The discovery of opioid receptors and endogenous substances capable of specific binding to these receptors, i.e. endorphin and enkephalin, is one of the most spectacular indications suggesting that the presence of a receptor for a certain drug in the organism authenticates searching for an endogenous substances with high affinity at this receptor ...
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The discovery of opioid receptors and endogenous substances capable of specific binding to these receptors, i.e. endorphin and enkephalin, is one of the most spectacular indications suggesting that the presence of a receptor for a certain drug in the organism authenticates searching for an endogenous substances with high affinity at this receptor ...
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